Correlation of Endolysmphatic Duct Signal Intensity With Clinical Features in Otological Diseases.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1097/mao.0000000000004309

Kosumo Matsui,Tadao Yoshida,Satofumi Sugimoto,Masumi Kobayashi,Shinji Naganawa,Michihiko Sone

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Abstract

OBJECTIVE Bilateral high signal intensity (SI) in the endolymphatic duct (ED) on magnetic resonance imaging (MRI) has been reported as a common characteristic in ears with large vestibular aqueduct syndrome (LVAS). However, the significance of bilateral high SI in the ED remains unknown. The present study aimed to compare the correlation between SI in the ED and the clinical manifestations in various otological disorders and consider the significance of the MRI findings. STUDY DESIGN Retrospective study. SETTING University hospital. PATIENTS The study included 2,450 ears from 1,225 patients with various otological disorders. INTERVENTION All ears underwent 3T enhanced MRI and were evaluated for the degree of endolymphatic hydrops (EH) and the SI ratios (SIRs; i.e., the calculation between SIs in the ED and those in the cerebellum). MAIN OUTCOME MEASURE The imaging findings were compared with their clinical symptoms. RESULTS Ears with bilateral high SIRs in the ED tended to have considerably less occurrence of EH in both the cochlea and vestibule than those with bilateral low SIRs. Ears with SIR ≥8 showed significantly elevated hearing thresholds at lower frequencies on pure-tone audiometry, although they exhibited a markedly lower incidence of cochlear EH than those with SIR <8. Moreover, ears with vertigo exhibited notably higher SIRs than those without vertigo. CONCLUSION Bilateral high SI in the ED on MRI may reflect pathophysiology underlying sensorineural hearing loss and vestibular symptoms, which are not associated with EH formation.

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咽鼓管内信号强度与耳科疾病临床特征的相关性

目的据报道，磁共振成像（MRI）显示的内淋巴管（ED）双侧高信号强度（SI）是大前庭导水管综合征（LVAS）患者耳朵的常见特征。然而，ED 双侧高 SI 的意义仍不清楚。本研究旨在比较 ED 中的 SI 与各种耳科疾病的临床表现之间的相关性，并考虑 MRI 发现的意义、主要结果测量将成像结果与临床症状进行比较。结果双侧内淋巴水肿 SIR 值较高的耳，其耳蜗和前庭的 EH 发生率往往大大低于双侧内淋巴水肿 SIR 值较低的耳。SIR≥8 的耳朵在纯音测听中的低频听阈明显升高，但其耳蜗 EH 的发生率明显低于 SIR＜8 的耳朵。此外，有眩晕的耳朵的 SIR 明显高于无眩晕的耳朵。结论在 ED 中，MRI 上的双侧高 SI 可能反映了感音神经性听力损失和前庭症状的病理生理学基础，这与 EH 的形成无关。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.