A novel molecular imprinted polymer grafted on N, S Co-doped carbon quantum dots-based fluorescence sensor for chloramphenicol in food and clinical samples

Abstract

Globally, antibiotic consumption surpasses thousands of tons on every year and even during this alarming state, the abundant traces of antibiotics have been found in the environment especially on water bodies and food producing creatures. The high accumulation of Chloramphenicol (CPL) may cause microbial resistance and lowering the general immunity. All these finding urges to develop a sensitive detection system for CPL. The present work describes the fabrication of Molecular Imprinted Polymer (MIP) grafted on Nitrogen and Sulfur doped Carbon Quantum Dots (N, S-CQDs) as a probe for the nanomolar level detection of CPL in food and clinical samples by using fluorescence technique. The developed N, S-CQDs based MIP sensor exhibits a bright fluorescence response and high recognition capability on CPL. The proposed sensor system has shown the detection limit of 7.65 nM and the linearity range was found between 0.24 μM and 26.1 μM. The real time consistency of the proposed sensor system has been verified by applying on clinical and food samples. Interestingly, we have received an excellent recovery varies from 97 % to 103 %. All these research outcomes further boost up the novel strategy to develop MIP based fluorescence probe for the detection of CPL.