Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation

IF 3.9 3区医学 Q2 CELL BIOLOGY

Pigment Cell & Melanoma Research Pub Date : 2024-09-18 DOI:10.1111/pcmr.13196

Erika Soria, Qiusheng Lu, Will Boswell, Kang Du, Yanting Xing, Mikki Boswell, Korri S. Weldon, Zhao Lai, Markita Savage, Manfred Schartl, Yuan Lu

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引用次数: 0

Abstract

Genetic interactions are adaptive within a species. Hybridization can disrupt such species‐specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative genetic interactions that decrease the overall hybrid survival and sterility, is one of the results from combining two diverged genomes in hybrids. The discovery of spontaneous lethal tumorigenesis and underlying genetic interactions in select hybrids between diverged Xiphophorus species showed that lethal pathological process can result from degenerative genetic interactions. Such genetic interactions leading to lethal phenotype are thought to shield gene flow between diverged species. However, hybrids between certain Xiphophorus species do not develop such tumors. Here we report the identification of a locus residing in the genome of one Xiphophorus species that represses an oncogene from a different species. Our finding provides insights into normal and pathological pigment cell development, regulation and a molecular mechanism in hybrid incompatibility.

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观赏基因与疾病驱动基因之间的分离为色素细胞调控提供了启示

在一个物种内，基因相互作用具有适应性。杂交会破坏这种物种特有的基因相互作用，并产生新的相互作用，从而改变杂交后代的整体适应性。杂交不亲和指的是退化性基因相互作用，会降低杂交后代的整体存活率和不育性，是两种不同基因组结合杂交的结果之一。在不同的 Xiphophorus 品种之间的杂交种中发现的自发致死性肿瘤发生和潜在的基因相互作用表明，退化性基因相互作用可能导致致死性病理过程。这种导致致死表型的基因交互作用被认为会阻碍不同物种之间的基因流动。然而，某些 Xiphophorus 物种之间的杂交种不会出现这种肿瘤。在这里，我们报告了在一个 Xiphophorus 物种的基因组中发现了一个位点，该位点能抑制来自不同物种的癌基因。我们的发现为正常和病理色素细胞的发育、调控以及杂交不相容的分子机制提供了启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pigment Cell & Melanoma Research 医学-皮肤病学

CiteScore

8.90

自引率

2.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders