First Case Report of Mycotic Abdominal Aortic Aneurysm Caused by Campylobacter fetus in Serbia

IF 3.3 3区 医学 Q2 MICROBIOLOGY
Deana Medic, Milica Devrnja, Nikola Batinic, Djordje Milosevic, Aleksandra Colovic Popadic, Vera Gusman
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Abstract

Background: Due to its distinct vascular tropism, Campylobacter fetus is recognized as a significant cause of severe systemic infections, especially in immunocompromised individuals, while it is rarely reported as a cause of gastrointestinal infections. Methods: A rare case of mycotic abdominal aortic aneurysm associated with Campylobacter fetus detected on the aneurysm wall itself was described. Results: A 68-year-old male was admitted to the hospital due to severe abdominal pain. The patient was afebrile, hemodynamically stable with elevated C-reactive protein levels. A physical examination revealed a palpable, pulsatile, tender mass located in the periumbilical region. Ultrasonography and multi-slice computer tomography angiography (MSCTA) identified an infrarenal abdominal aortic aneurysm with a maximum diameter of 6.5 cm, showing suspicious signs of dissection. Aneurysmectomy with Dacron tube graft interposition was performed. Although the blood cultures remained negative, the culture of the aneurysmal wall grew Campylobacter fetus, enabling early diagnosis and targeted antibiotic therapy. The patient was treated with meropenem for two weeks, followed by amoxicillin-clavulanate for another two weeks after hospital discharge. Conclusions: Campylobacter fetus associated with abdominal aortic aneurysms represents a life-threatening condition, posing a significant challenge in vascular surgery. Due to the lack of clear guidelines on antibiotic susceptibility testing and the treatment of infections associated with this pathogen, enhanced surveillance of Campylobacter fetus is necessary in both human and veterinary medicine.
塞尔维亚首例由胎儿弯曲杆菌引起的霉菌性腹主动脉瘤病例报告
背景:胎儿弯曲杆菌因其独特的血管滋养特性,被认为是导致严重全身感染的重要原因,尤其是在免疫力低下的人群中,但很少有报道称其会导致胃肠道感染。方法:描述了一例罕见的霉菌性腹主动脉瘤病例,该病例在动脉瘤壁上发现了胎儿弯曲杆菌。结果一名 68 岁的男性因剧烈腹痛入院。患者无发热,血流动力学稳定,C 反应蛋白水平升高。体格检查发现位于脐周的可触及、搏动性、压痛性肿块。超声波检查和多层计算机断层扫描血管造影术(MSCTA)发现了一个最大直径为 6.5 厘米的肾下腹主动脉瘤,有可疑的夹层迹象。患者接受了动脉瘤切除术和达克龙管移植术。虽然血液培养结果仍为阴性,但动脉瘤壁培养出了胎儿弯曲杆菌,从而得以早期诊断并进行针对性的抗生素治疗。患者接受了为期两周的美罗培南治疗,出院后又接受了为期两周的阿莫西林-克拉维酸治疗。结论腹主动脉瘤伴发胎儿弯曲杆菌是一种威胁生命的疾病,给血管外科手术带来了巨大挑战。由于对该病原体相关的抗生素敏感性检测和感染治疗缺乏明确的指导原则,因此人类和兽医都有必要加强对胎儿弯曲杆菌的监控。
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来源期刊
Pathogens
Pathogens Medicine-Immunology and Allergy
CiteScore
6.40
自引率
8.10%
发文量
1285
审稿时长
17.75 days
期刊介绍: Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.
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