Prevalence of intestinal parasites and Helicobacter pylori coinfection, and contributing factors among patients with gastrointestinal manifestations at Addis Zemen primary hospital, Northwest Ethiopia

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2024-09-19 DOI:10.1186/s13099-024-00642-8

Andargachew Almaw, Ayenew Berhan, Addisu Ayele, Alemie Fentie, Aynework Abebaw, Birhanemaskal Malkamu, Birhanu Getie, Mulat Erkihun, Yenealem Solomon, Tahir Eyayu, Teklehaimanot Kiros

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引用次数: 0

Abstract

The urease-producing Helicobacter pylori increase the likelihood that pathogenic intestinal protozoa will use the stomach’s increased hydrogen potential to propagate the disease. Coinfections exacerbate the onset and severity of gastrointestinal symptoms. This study aimed to assess the prevalence of intestinal parasites/Helicobacter pylori coinfection and contributing factors in patients with gastrointestinal symptoms at Addis Zemen Primary Hospital, Northwest Ethiopia. From April to July 2023, patients with gastrointestinal problems participated in a cross-sectional study carried out in a hospital. To collect the clinical and sociodemographic data, a questionnaire was employed. Intestinal parasites and Helicobacter pylori were detected using the saline stool wet mount and Helicobacter pylori stool antigen tests, respectively. SPSS version 20 was used to analyze the data and variables with p-values < 0.05 were considered statistically significant. The study included 384 participants in total, of which 47.3% (182/384) were farmers and 50.3% (193/384) were women. Of the study subjects, 69/384 or approximately 18%, had intestinal parasitic infections. In 12% of cases (46/384), Helicobacter pylori were detected. A coinfection of Helicobacter pylori and intestinal parasites was found in 5.5% (21/384) of the subjects. Multiple logistic regression revealed increased risk of coinfection of Helicobacter pylori and intestinal parasites in patients who drink surface water (AOR: 10.7, p = 0.03) family history of Helicobacter pylori (AOR: 3.3, p = 0.024) and those with untrimmed fingers (AOR: 4.9, p = 0.031). Giardia lamblia and Entamoeba histolytica/dispar/ moshkovskii/ bangladeshi complex are the most common protozoans that cause coinfection with Helicobacter pylori. Drinking surface water, family history of Helicobacter pylori and untrimmed fingers are the contributing factors to intestinal parasites/Helicobacter pylori coinfection.

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埃塞俄比亚西北部亚的斯亚贝巴泽门初级医院胃肠道症状患者肠道寄生虫和幽门螺旋杆菌合并感染的流行率及诱因

产生尿素酶的幽门螺旋杆菌会增加致病性肠道原生动物利用胃中增加的氢潜能繁殖疾病的可能性。合并感染会加剧胃肠道症状的出现和严重程度。本研究旨在评估埃塞俄比亚西北部阿迪斯泽门初级医院胃肠道症状患者肠道寄生虫/幽门螺杆菌合并感染的发病率和诱因。2023 年 4 月至 7 月，胃肠道疾病患者参加了医院开展的一项横断面研究。为了收集临床和社会人口数据，研究人员采用了问卷调查的方式。使用生理盐水粪便湿装载法和幽门螺旋杆菌粪便抗原检测法分别检测了肠道寄生虫和幽门螺旋杆菌。数据分析采用 SPSS 20 版，P 值小于 0.05 的变量被视为具有统计学意义。研究共纳入 384 名参与者，其中 47.3%（182/384）为农民，50.3%（193/384）为女性。研究对象中有 69/384 人（约占 18%）感染了肠道寄生虫。12%的病例（46/384）检测出幽门螺旋杆菌。5.5%的受试者（21/384）同时感染幽门螺旋杆菌和肠道寄生虫。多重逻辑回归显示，饮用地表水的患者（AOR：10.7，p = 0.03）、有幽门螺旋杆菌家族史的患者（AOR：3.3，p = 0.024）和手指未修剪的患者（AOR：4.9，p = 0.031）同时感染幽门螺旋杆菌和肠道寄生虫的风险增加。蓝氏贾第鞭毛虫和组织溶解恩塔米巴虫/dispar/moshkovskii/孟加拉复合体是导致幽门螺旋杆菌合并感染的最常见原生动物。饮用地表水、幽门螺旋杆菌家族史和未修剪的手指是肠道寄生虫/幽门螺旋杆菌合并感染的诱因。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).