Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension.

IF 2.9 2区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Biomedical optics express Pub Date : 2024-08-27 DOI:10.1364/boe.529150

Wesley B Baker,Rodrigo M Forti,Pascal Heye,Kristina Heye,Jennifer M Lynch,Arjun G Yodh,Daniel J Licht,Brian R White,Misun Hwang,Tiffany S Ko,Todd J Kilbaugh

引用次数: 0

Abstract

We introduce a frequency-domain modified Beer-Lambert algorithm for diffuse correlation spectroscopy to non-invasively measure flow pulsatility and thus critical closing pressure (CrCP). Using the same optical measurements, CrCP was obtained with the new algorithm and with traditional nonlinear diffusion fitting. Results were compared to invasive determination of intracranial pressure (ICP) in piglets (n = 18). The new algorithm better predicted ICP elevations; the area under curve (AUC) from logistic regression analysis was 0.85 for ICP ≥ 20 mmHg. The corresponding AUC for traditional analysis was 0.60. Improved diagnostic performance likely results from better filtering of extra-cerebral tissue contamination and measurement noise.

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用于测量搏动性血流、临界关闭压和颅内高压的改良比尔-朗伯算法。

我们为弥散相关光谱学引入了一种频域修正比尔-朗伯算法，用于无创测量流动脉动性，从而测量临界关闭压力（CrCP）。使用相同的光学测量方法，用新算法和传统的非线性扩散拟合方法获得了临界关闭压（CrCP）。结果与有创测定仔猪（n = 18）颅内压（ICP）的结果进行了比较。新算法能更好地预测 ICP 升高；ICP ≥ 20 mmHg 时，逻辑回归分析的曲线下面积 (AUC) 为 0.85。而传统分析的相应 AUC 为 0.60。诊断性能的提高可能是由于更好地过滤了脑外组织污染和测量噪音。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS

CiteScore

6.80

自引率

11.80%

发文量

633

审稿时长

1 months

期刊介绍： The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.