Lipid Redistribution due to a Cell-Cell Fusion Pore.

IF 3.2 3区生物学 Q2 BIOPHYSICS

Biophysical journal Pub Date : 2024-09-17 DOI:10.1016/j.bpj.2024.09.015

David William Allender,Michael Schick

引用次数: 0

Abstract

We consider the redistribution of lipids comprising the plasma membranes during cell-cell fusion, particularly due to the presence of a fusion pore. Assuming the membranes are of constant thickness, we find that the mole fraction of cholesterol increases in the directly apposed exoplasmic leaflets, and is decreased in the cytoplasmic leaflets. The redistribution of the phospholipids is obtained as well.

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细胞-细胞融合孔导致的脂质再分布

我们考虑了细胞-细胞融合过程中组成质膜的脂质的重新分布，特别是由于融合孔的存在。假设膜的厚度不变，我们发现胆固醇的摩尔分数在直接贴合的外质小叶中增加，而在细胞质小叶中减少。磷脂的重新分布也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysical journal 生物-生物物理

CiteScore

6.10

自引率

5.90%

发文量

3090

审稿时长

2 months

期刊介绍： BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.