Synaptotagmin-1 in phase: Condensate biology reveals new insights into the synaptic calcium sensor.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-09-17 DOI:10.1083/jcb.202408073

Johannes Vincent Tromm,Dragomir Milovanovic

引用次数: 0

Abstract

Two recent papers by Mehta et al. and Zhu et al. in this issue (https://doi.org/10.1083/jcb.202311191) discover that synaptotagmin-1, the primary calcium sensor at the synapse, forms biomolecular condensates, identifying a new layer of regulation in calcium-triggered synaptic vesicle exocytosis.

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相位突触钙敏蛋白-1：凝结生物学揭示突触钙传感器的新见解

本期（https://doi.org/10.1083/jcb.202311191）刊载的Mehta等人和Zhu等人的两篇最新论文发现，突触中的主要钙离子传感器--突触塔格明-1会形成生物分子凝聚物，从而确定了钙离子触发的突触囊泡外泌过程中的一个新的调控层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.