Assessment on the Personal Exposure Risk Associated With Real-Time Indoor PM2.5 in Different Microenvironments

IF 4.3 2区 环境科学与生态学 Q1 CONSTRUCTION & BUILDING TECHNOLOGY
Indoor air Pub Date : 2024-09-17 DOI:10.1155/2024/2236778
Shuiping Dai, Yuhang He, Ni Zeng, Zhenglu Wang
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Abstract

The cytotoxicity of PM2.5 (fine particulate) derived from varying fuels burning in different microenvironments remains unclear. In this study, the toxicity of PM2.5 collected from northern China in the winter on human cervical carcinoma (HeLa) cells was determined. The PM2.5 from chunk coal (CC) combustion caused greater apoptosis (22.47%) than firewood (FW) burning (5.32%), while the effects on cell viability showed contrary patterns between FW (stimulation: 132.38%) and CC (inhibition: 87.05%). Furthermore, all the samples induced significant oxidative stress and inflammatory responses in cells. Intriguingly, PM2.5 samples collected from FW burning upregulated the expression genes involved in pathways in cancer, whereas those from CC burning downregulated the levels. Accordingly, the health risks of different samples were assessed through a probabilistic model. The risk level of samples of CC burning from the living room (CC/L) was 0.752, followed by CC from the bedroom (CC/B, 0.736), and then CC from the kitchen (CC/K, 0.562), FW without a chimney (FW-C, 0.451), and FW with a chimney (FW+C, 0.446). Meanwhile, the survival curves established by gene expression indicated that PM2.5 from FW might be positively correlated with cancer progression. This pilot investigation demonstrated that CC combustion in the living room posed the highest health risk, and improved cookstoves (with a chimney) markedly reduced the risk. This pilot study presents a novel model for assessing health risks associated with air pollution using the toxicology method and real-time PM2.5 quantification.

Abstract Image

不同微环境下与实时室内 PM2.5 相关的个人暴露风险评估
不同燃料在不同微环境中燃烧产生的 PM2.5(细颗粒物)的细胞毒性尚不清楚。本研究测定了中国北方冬季采集的 PM2.5 对人宫颈癌(HeLa)细胞的毒性。大块煤(CC)燃烧产生的PM2.5导致的细胞凋亡率(22.47%)高于木柴(FW)燃烧产生的PM2.5导致的细胞凋亡率(5.32%),而木柴(刺激:132.38%)和大块煤(CC)燃烧产生的PM2.5(抑制:87.05%)对细胞活力的影响呈现相反的模式。此外,所有样本都会诱导细胞产生明显的氧化应激和炎症反应。耐人寻味的是,燃烧 FW 所采集的 PM2.5 样品会上调癌症相关通路基因的表达,而燃烧 CC 所采集的 PM2.5 样品则会下调这些基因的表达水平。因此,我们通过概率模型评估了不同样本的健康风险。客厅燃烧 CC(CC/L)样本的风险水平为 0.752,其次是卧室燃烧 CC(CC/B,0.736),然后是厨房燃烧 CC(CC/K,0.562)、无烟囱燃烧 FW(FW-C,0.451)和有烟囱燃烧 FW(FW+C,0.446)。同时,通过基因表达建立的生存曲线表明,FW产生的PM2.5可能与癌症进展呈正相关。这项试点调查表明,在起居室燃烧 CC 对健康造成的风险最高,而改良炉灶(带烟囱)则明显降低了这种风险。这项试点研究提出了一种利用毒理学方法和实时 PM2.5 定量评估与空气污染相关的健康风险的新模式。
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来源期刊
Indoor air
Indoor air 环境科学-工程:环境
CiteScore
10.80
自引率
10.30%
发文量
175
审稿时长
3 months
期刊介绍: The quality of the environment within buildings is a topic of major importance for public health. Indoor Air provides a location for reporting original research results in the broad area defined by the indoor environment of non-industrial buildings. An international journal with multidisciplinary content, Indoor Air publishes papers reflecting the broad categories of interest in this field: health effects; thermal comfort; monitoring and modelling; source characterization; ventilation and other environmental control techniques. The research results present the basic information to allow designers, building owners, and operators to provide a healthy and comfortable environment for building occupants, as well as giving medical practitioners information on how to deal with illnesses related to the indoor environment.
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