Unlocking the Potential: PEGylation and Molecular Weight Reduction of Ionenes for Enhanced Antifungal Activity and Biocompatibility

IF 4.4 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Macromolecular bioscience Pub Date : 2024-09-16 DOI:10.1002/mabi.202470022

Jan M. Kurzyna, Rafał J. Kopiasz, Martyna Paul, Magdalena Flont, Patrycja Baranowska, Jolanta Mierzejewska, Karolina Drężek, Waldemar Tomaszewski, Elżbieta Jastrzębska, Dominik Jańczewski

引用次数: 0

Abstract

Back Cover: Synthetic polymers mimicking antimicrobial peptides show potent activity but high toxicity. This study's cationic ionenes, modified with a PEG side chain, exhibited high antimicrobial activity and reduced toxicity. Remarkably, lower molecular weight increased antifungal activity, with MICs as low as 2 and 0.0625 µg/mL for C. albicans and C. tropicalis. More details can be found in article 2400032 by Dominik Jańczewski and co-workers.

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释放潜力：离子烯的 PEG 化和分子量降低可增强抗真菌活性和生物相容性

封底：模仿抗菌肽的合成聚合物具有强效活性，但毒性较高。这项研究的阳离子烯经 PEG 侧链修饰后，显示出很高的抗菌活性，同时毒性降低。值得注意的是，分子量越低，抗真菌活性越强，对白僵菌和热带僵菌的 MIC 值分别低至 2 微克/毫升和 0.0625 微克/毫升。更多详情，请参阅 Dominik Jańczewski 及其合作者撰写的文章 2400032。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.