Cover Feature: Synthesis and Thermodynamic Evaluation of Sialyl-Tn MUC1 Glycopeptides Binding to Macrophage Galactose-Type Lectin (ChemBioChem 18/2024)

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-16 DOI:10.1002/cbic.202481804

Ramya Ayyalasomayajula, Ivet Boneva, David Ormaza, Andrew Whyte Jr., Kamran Farook, Zachary Gorlin, Evelyn Yancey, Sabine André, Herbert Kaltner, Maré Cudic

引用次数: 0

Abstract

Isothermal titration calorimetry (ITC) analysis of the binding of hMGL to Tn and sialyl-Tn MUC1 glycopeptides revealed a dynamic process in which lectin molecules bind to carbohydrate ligands and jump from ligand to ligand along the glycopeptides’ backbone. More details can be found in article 10.1002/cbic.202400391 by Maré Cudic and co-workers.

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封面专题：与巨噬细胞半乳糖型凝集素结合的 Sialyl-Tn MUC1 糖肽的合成与热力学评估（ChemBioChem 18/2024）

对 hMGL 与 Tn 和 sialyl-Tn MUC1 糖肽结合的等温滴定量热法（ITC）分析表明了一个动态过程，在这个过程中，凝集素分子与碳水化合物配体结合，并沿着糖肽骨架从一个配体跳到另一个配体。更多详情请见 Maré Cudic 及其合作者撰写的文章 10.1002/cbic.202400391。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464