Dr. Jinchao Lou, Dr. Christelle F. Ancajas, Dr. Yue Zhou, Nicolas S. Lane, Prof. Dr. Todd B. Reynolds, Prof. Michael D. Best
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引用次数: 0
Abstract
The cover image depicts the development of a strategy for the general labeling of glycerophospholipids in cells. To accomplish this goal, a caged glycerol-3-phosphate probe containing a clickable azide tag is designed and synthesized. Incorporation of the click tag within the glycerol region enable hijacking of lipid biosynthetic pathways to produce labeled versions of a variety of glycerolipids. In the cover image, the process of lipid metabolic labeling in cells is reimagined as an automated assembly-line process for the mass production of labeled lipid molecules. More details can be found in the Research Article 10.1002/cbic.202300853 by Michael D. Best and co-workers.
封面图片描述了一种对细胞中甘油磷脂进行一般标记的策略的开发过程。为了实现这一目标，我们设计并合成了一种含有可点击叠氮标签的甘油-3-磷酸酯笼式探针。在甘油区域加入点击标签，就能劫持脂质生物合成途径，生成各种甘油酯的标记版本。在封面图片中，细胞中的脂质代谢标记过程被重新想象为大规模生产标记脂质分子的自动化流水线过程。更多详情，请参阅 Michael D. Best 及其合作者的研究文章 10.1002/cbic.202300853。
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