Brain–computer interface for simultaneous dual-region spatial coding in hippocampal and somatosensory cortex of freely behaving rats

IF 0.7 4区工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC

Electronics Letters Pub Date : 2024-09-17 DOI:10.1049/ell2.70013

Ming Li, Wei Xu, Zhaojie Xu, Fan Mo, Gucheng Yang, Shiya Lv, Hanwen Cao, Juntao Liu, Xinxia Cai

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Abstract

Decoding of spatial information from place cells is currently limited to individual brain regions, severely constraining the understanding of the brain's spatial navigation mechanisms. In this study, synchronized detection of dual-brain region spatial encoding was conducted using brain–computer interface (BCI). Therefore, an implantable microelectrode array (MEA) was developed tailored for the simultaneous detection of neuronal activities in the CA1 of the hippocampus and the Barrel Cortex (BC) of the somatosensory cortex in rats as BCI. The MEA was improved by modifying the nanocomposite PtNP/PEDOT:PSS to improve their electrical properties (reducing impedance from 1.82 ± 0.17 MΩ to 3.4 ± 0.3 kΩ), facilitating neural recordings in freely behaving rats. The neural activities were obtained from the CA1 and the BC simultaneously and validated the existence of place cells in both brain regions. This study highlighted the potential of PtNP/PEDOT:PSS-modified MEA as BCI in concurrently detecting neural activity associated with spatial encoding in two brain regions, offering novel perspectives on the processing of tactile stimuli and the formation of cognitive maps for navigation.

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在自由行为大鼠的海马和体感皮层同时进行双区空间编码的脑机接口

目前，对来自位置细胞的空间信息的解码仅限于单个脑区，这严重限制了对大脑空间导航机制的了解。本研究利用脑机接口（BCI）对双脑区空间编码进行同步检测。因此，研究人员开发了一种植入式微电极阵列（MEA），用于同时检测大鼠海马CA1和体感皮层桶状皮层（BC）的神经元活动，并将其作为BCI。通过改性纳米复合材料 PtNP/PEDOT:PSS 改善了 MEA 的电学特性（阻抗从 1.82 ± 0.17 MΩ 降至 3.4 ± 0.3 kΩ），从而促进了自由行为大鼠的神经记录。该研究同时获得了 CA1 和 BC 的神经活动，并验证了这两个脑区都存在位置细胞。这项研究强调了 PtNP/PEDOT:PSS 改性 MEA 作为 BCI 在同时检测两个脑区与空间编码相关的神经活动方面的潜力，为触觉刺激的处理和导航认知地图的形成提供了新的视角。

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来源期刊

Electronics Letters 工程技术-工程：电子与电气

CiteScore

2.70

自引率

0.00%

发文量

268

审稿时长

3.6 months

期刊介绍： Electronics Letters is an internationally renowned peer-reviewed rapid-communication journal that publishes short original research papers every two weeks. Its broad and interdisciplinary scope covers the latest developments in all electronic engineering related fields including communication, biomedical, optical and device technologies. Electronics Letters also provides further insight into some of the latest developments through special features and interviews. Scope As a journal at the forefront of its field, Electronics Letters publishes papers covering all themes of electronic and electrical engineering. The major themes of the journal are listed below. Antennas and Propagation Biomedical and Bioinspired Technologies, Signal Processing and Applications Control Engineering Electromagnetism: Theory, Materials and Devices Electronic Circuits and Systems Image, Video and Vision Processing and Applications Information, Computing and Communications Instrumentation and Measurement Microwave Technology Optical Communications Photonics and Opto-Electronics Power Electronics, Energy and Sustainability Radar, Sonar and Navigation Semiconductor Technology Signal Processing MIMO