Trajano Aguiar Pires Gonçalves , Juliana Naback Toniolo , Matheus Compart Hemerly , Maria Clara Zanon Zotin , Anna Letícia de Moraes Alves , Katharina Vieira Messias , Vanessa Daccach Marques
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引用次数: 0
Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a rare hematological malignancy where its development in the intravascular environment is the main characteristic. Despite its ability to affect multiple organic systems, there is a tropism for the central nervous system, which may be related to several clinical syndromes, making this condition a great mimic and consequently a diagnostic challenge. Rapidly progressive dementia may be one of the presenting phenotypes of IVLBCL. This case report aims to highlight the main red flags, such as sustained elevation of lactate dehydrogenase, organomegaly and specific lesions with vasculitis-like bleeding, all that can be used as clinical clues to direct the differential diagnosis. In addition, it reinforces the role of early brain biopsy in this context, since IVLBCL is a treatable disease.
血管内大 B 细胞淋巴瘤（IVLBCL）是一种罕见的血液恶性肿瘤，其主要特征是在血管内环境中发展。尽管它能影响多个器官系统，但它对中枢神经系统有趋向性，这可能与多种临床综合征有关，因此这种疾病的模仿性很强，也是诊断上的一个难题。快速进展性痴呆可能是IVLBCL的表现型之一。本病例报告旨在强调主要的警示信号，如乳酸脱氢酶持续升高、器官肿大和伴有血管炎样出血的特殊病变，所有这些都可以作为临床线索来指导鉴别诊断。此外，报告还强调了早期脑活检在这种情况下的作用，因为IVLBCL是一种可以治疗的疾病。
期刊介绍：
The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.
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