Cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-09-13 DOI:10.1016/j.neurobiolaging.2024.09.006

Feng Deng , Maria-Eleni Dounavi , Emanuele R.G. Plini , Karen Ritchie , Graciela Muniz-Terrera , Siobhan Hutchinson , Paresh Malhotra , Craig W. Ritchie , Brian Lawlor , Lorina Naci

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引用次数: 0

Abstract

Alzheimer’s Disease (AD) neuropathology start decades before clinical manifestations, but whether risk factors are associated with early cognitive and brain changes in midlife remains poorly understood. We examined whether AD risk factors were associated with cognition and functional connectivity (FC) between the Locus Coeruleus (LC) and hippocampus – two key brain structures in AD neuropathology – cross-sectionally and longitudinally in cognitively healthy midlife individuals. Neuropsychological assessments and functional Magnetic Resonance Imaging were obtained at baseline (N=210), and two-years follow-up (N=188). Associations of cognition and FC with apolipoprotein ε4 (APOE ε4) genotype, family history of dementia, and the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score were investigated. Cross-sectionally, higher CAIDE scores were associated with worse cognition. Menopausal status interacted with the CAIDE risk on cognition. Furthermore, the CAIDE score significantly moderated the relationship between cognition and LC–Hippocampus FC. Longitudinally, the LC–Hippocampus FC decreased significantly over 2 years. These results suggest that cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals.

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痴呆症的心血管风险与认知健康的中年人大脑行为变化有关

阿尔茨海默病（AD）的神经病理学始于临床表现之前的几十年，但人们对风险因素是否与中年早期认知和大脑变化相关仍知之甚少。我们对认知健康的中年人进行了横向和纵向研究，探讨了老年痴呆症的风险因素是否与认知能力以及与老年痴呆症神经病理有关的两个关键大脑结构--灶部小脑（LC）和海马--之间的功能连接（FC）有关。在基线（210 人）和两年随访（188 人）期间进行了神经心理学评估和功能磁共振成像。研究人员调查了认知能力和功能障碍与载脂蛋白ε4（APOE ε4）基因型、痴呆症家族史以及心血管风险因素、衰老和痴呆症发病率（CAIDE）评分的关系。从横截面来看，CAIDE评分越高，认知能力越差。更年期状态与认知能力的 CAIDE 风险相互影响。此外，CAIDE评分还能明显调节认知能力与LC-海马体FC之间的关系。纵向来看，LC-海马体FC在2年内明显下降。这些结果表明，在认知健康的中年人中，痴呆症的心血管风险与大脑行为变化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.