Expanding the horizons of photodynamic therapy: Indium metalated pyridinyl-based trans-A2B2 porphyrin as novel anti-biofilm agents

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-09-13 DOI:10.1016/j.dyepig.2024.112448

James Oyim , Aviwe Magadla , John Mack , Edith Amuhaya , Tebello Nyokong

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Abstract

Modern medicine is exploring new approaches to combat bacterial infections associated with antibiotic-resistant bacteria and biofilms. Among these, antimicrobial photodynamic therapy (aPDT) stands out for its ability to target pathogenic microbes effectively. In this study, we investigated the antimicrobial potential of the newly synthesized indium metalated pyridinyl-based trans-A₂B₂ porphyrin complexes, 1a,b and 2a,b. The dicationic porphyrins, 1b and 2b, exhibited remarkable aPDT efficacy against both S. aureus and E. coli planktonic forms. Further investigation into the antimicrobial effects of the cationic porphyrins against E. coli and S. aureus biofilms revealed that both complexes (1b and 2b) exhibited high efficacy in aPDT attributed to tert-butyl and thiophene groups that enhance photo-physicochemical properties and bacterial membrane accumulation. Scanning electron microscopy (SEM) showed disruption of cell membranes following light exposure. Our work highlights the potential of aPDT as an effective strategy for managing biofilms. By harnessing the power of these innovative compounds, we contribute to the ongoing battle against microbial threats.

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拓展光动力疗法的视野：铟金属化吡啶基反式-A2B2卟啉作为新型抗生物膜剂

现代医学正在探索新的方法，以应对与抗生素耐药细菌和生物膜相关的细菌感染。其中，抗菌光动力疗法（aPDT）因其能有效针对病原微生物而脱颖而出。在本研究中，我们研究了新合成的铟金属化吡啶基反式-A2B2卟啉复合物 1a,b 和 2a,b 的抗菌潜力。二阳离子卟啉 1b 和 2b 对金黄色葡萄球菌和大肠杆菌的浮游生物均有显著的抗菌效果。进一步研究阳离子卟啉对大肠杆菌和金黄色葡萄球菌生物膜的抗菌效果发现，这两种复合物（1b 和 2b）都表现出很高的抗原性滴滴涕功效，这归功于叔丁基和噻吩基团增强了光物理化学特性和细菌膜积累。扫描电子显微镜（SEM）显示，光照射后细胞膜会被破坏。我们的工作凸显了 aPDT 作为管理生物膜的有效策略的潜力。通过利用这些创新化合物的力量，我们为正在进行的抗击微生物威胁的斗争做出了贡献。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.