An update of isoprostanoid nomenclature

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2024-09-14 DOI:10.1016/j.plipres.2024.101301

Camille Oger , Tereza Pavlíčková , Valérie Bultel-Poncé , Alexandre Guy , Jean-Marie Galano , Ullrich Jahn , Thierry Durand

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Abstract

Polyunsaturated fatty acids (PUFAs) play numerous roles in living organisms but are also prone to rapid aerobic oxidation, resulting in the production of a wide range of isomeric metabolites called oxylipins. Among these, isoprostanes, discovered in the 1990s, are formed non-enzymatically from ω–3 and ω–6 PUFAs with 16 to 22 carbon atoms. Over nearly 35 years of research, two nomenclature systems for isoprostanes have been proposed and have evolved. However, as research progresses, certain aspects of the current nomenclature remain unclear and require further clarification to ensure precise identification of each metabolite and its corresponding parent PUFA. Therefore, we propose an update to the current nomenclature system, along with practical guidelines for assessing isoprostanoid diversity and identifying their PUFA origins.

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更新异甾烷类命名法

多不饱和脂肪酸（PUFAs）在生物体内发挥着多种作用，但也容易被快速有氧氧化，从而产生多种异构代谢物，称为氧脂素。其中，20 世纪 90 年代发现的异前列素是由ω-3 和ω-6 脂肪酸（具有 16 至 22 个碳原子）非酶促形成的。在近 35 年的研究过程中，提出并逐渐形成了两种异前列素命名系统。然而，随着研究的深入，目前命名法的某些方面仍不明确，需要进一步澄清，以确保准确识别每种代谢物及其相应的母体 PUFA。因此，我们建议更新当前的命名系统，并提供实用指南，用于评估异丙类固醇的多样性并确定其 PUFA 的来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.