As-deposited and dewetted Cu layers on plasma treated glass: Adhesion study and its effect on biological response

IF 7.5 Q1 CHEMISTRY, PHYSICAL
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Abstract

Improving the adhesion of nanosized copper films to a glass substrate is vital for their application in electronics and medicine, as it enhances their overall reliability. For this purpose, we employed Ar plasma etching (240 s) and magnetron sputtering to create copper layers on a glass substrate. Furthermore, we investigated the effect of subsequent solid state dewetting (at 300 °C) of Cu nanolayers on the interface stability. Increasing the sputtering time resulted in elevated copper concentration, UV-Vis absorption, conductivity, and surface roughness. The as-deposited and dewetted samples exhibited very good wettability with water contact angles below 60°. Importantly, plasma treatment improved the adhesion of the Cu layers to the glass. Subsequent dewetting accelerated surface diffusion and the oxidation of Cu atoms, causing structural and morphological changes. The presence of CuO after dewetting caused loss of the surface plasmon resonance (SPR) band in the UV-Vis spectrum and a decrease in sample conductivity due to the transformation of the copper layer from a metal to an oxide. Biological testing revealed a more pronounced bactericidal effect for the as-deposited Cu layer against E. coli and S. epidermidis on contrary to dewetted samples. The similar cytotoxic trend was observed for human dermal fibroblasts and hepatocytes. Nonetheless, biological testing confirmed better cell adhesion on dewetted Cu layers compared to the as-deposited ones. Therefore, our copper nanostructured samples could find application as antibacterial coatings of biomedical devices.

Abstract Image

等离子处理玻璃上的砷沉积和脱水铜层:附着力研究及其对生物反应的影响
提高纳米铜膜与玻璃基底的附着力对其在电子和医药领域的应用至关重要,因为这可以增强其整体可靠性。为此,我们采用了氩等离子刻蚀(240 秒)和磁控溅射技术在玻璃基底上形成铜层。此外,我们还研究了铜纳米层后续固态脱胶(300 °C)对界面稳定性的影响。增加溅射时间会导致铜浓度、紫外可见吸收率、电导率和表面粗糙度升高。经过沉积和脱水处理的样品具有非常好的润湿性,水接触角低于 60°。重要的是,等离子处理提高了铜层与玻璃的附着力。随后的脱水加速了铜原子的表面扩散和氧化,导致结构和形态发生变化。脱水后 CuO 的存在导致紫外-可见光谱中表面等离子体共振 (SPR) 波段的消失,同时由于铜层从金属转变为氧化物,样品的导电性降低。生物测试表明,与经过脱水处理的样品相比,经过沉积的铜层对大肠杆菌和表皮葡萄球菌具有更明显的杀菌效果。人类真皮成纤维细胞和肝细胞也观察到了类似的细胞毒性趋势。不过,生物测试证实,与沉积后的铜层相比,脱水后的铜层具有更好的细胞粘附性。因此,我们的纳米铜结构样品可用作生物医学设备的抗菌涂层。
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来源期刊
CiteScore
8.10
自引率
1.60%
发文量
128
审稿时长
66 days
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