Biological functions of extracellular vesicles from mammalian cells

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2024-09-12 DOI:10.1016/j.bj.2024.100788

Jean M. Kanellopoulos, Frédéric Rieux-Laucat, David M. Ojcius

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are enclosed by a phospholipid bilayer and can be secreted by most types of cells. EVs deliver cargo from the secreting cell into the cytoplasm of recipient cells, influencing the function of the recipient cells. EVs are attracting increasing attention from a broad range of clinicians and scientists due to their ability to promote or inhibit various physiological pathways or pathological conditions. This special issue of Biomedical Journal contains articles describing the biogenesis and biodistribution of EVs and their role in the intercellular transfer of various molecules or viruses to target cells, in rejecting allogeneic transplants and maintaining immune tolerance of the allogeneic fetus, and in modulating innate and adaptive immunity. Characterization of the role of EVs in various pathological conditions and our ability to engineer modified EVs may lead to discovery of novel biomarkers and development of therapeutic strategies for treatment of disease.

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哺乳动物细胞外囊泡的生物功能

细胞外小泡（EVs）由磷脂双分子层包裹，可由大多数类型的细胞分泌。EVs将货物从分泌细胞输送到受体细胞的细胞质中，从而影响受体细胞的功能。由于EVs具有促进或抑制各种生理途径或病理状况的能力，因此越来越受到广大临床医生和科学家的关注。本期《生物医学杂志》特刊收录的文章介绍了 EVs 的生物发生和生物分布，以及它们在细胞间将各种分子或病毒转移到靶细胞、排斥异体移植和维持异体胎儿免疫耐受以及调节先天性免疫和适应性免疫中的作用。研究 EVs 在各种病理情况下的作用以及我们改造 EVs 的能力，可能会发现新的生物标记物，并开发出治疗疾病的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.