Dietary nicotinamide improves growth performance and ameliorates liver lipid profiles by alleviating glycerophospholipid and sphingolipids metabolism in swamp eel (Monopterus albus)

IF 3.2 2区农林科学 Q1 FISHERIES

Aquaculture Reports Pub Date : 2024-09-19 DOI:10.1016/j.aqrep.2024.102361

Wanming Song , Bihui Chao , Mingjin Yu , Ruixue Jin , Xiao Chen , Yazhou Zhang , Chuanqi Yu , Zirui Wang , Qiubai Zhou , Zhuqing Yang

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Abstract

The effect of dietary niacinamide (NAM) on the growth performance and liver lipid metabolism of swamp eel have been poorly investigated. Therefore, a 120-day feeding trial was conducted to provide different levels of NAM in diet and an untargeted lipidome analysis was performed to address this subject. We found that dietary NAM improved the growth performance of swamp eel. It also decreased the contents of glucose and lipids, including glucose, glycogen, TG, and NEFA, as well as fat accumulation in liver, but increased HDL-C content. We speculated that NAM inhibited lipid accumulation in liver by decreasing the key enzyme activity of LPL, HL and LPS. Fatty acid profile analysis showed that the contents of MUFA and PUFA, such as palmitoleic acid, oleic acid, and eicosapentaenoic acid were significantly increased, while the contents of SFA, such as myristic acid, stearic acid, and palmitic acid were decreased in liver by dietary NAM. Lipidome analysis also indicated that the majority of differential lipid metabolites belonged to glycerophospholipids and sphingolipids, which were enriched in the pathways of insulin resistance, adipocytokine signaling pathway, cholesterol metabolism, fat digestion and absorption, lipid and atherosclerosis, and lipid cell lipolysis regulation. These findings gave scientific evidences and novel insights into the metabolic responses to dietary NAM in swamp eel, and provided basic knowledge for using NAM as a feed additive in swamp eel production.

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通过缓解甘油磷脂和鞘磷脂代谢，膳食烟酰胺可改善沼泽鳗鱼的生长性能和肝脂状况

关于日粮中烟酰胺（NAM）对沼泽鳗鱼生长性能和肝脏脂质代谢的影响的研究很少。因此，我们进行了一项为期 120 天的喂养试验，在日粮中提供不同水平的烟酰胺，并进行了非靶向脂质体分析，以解决这一问题。我们发现，膳食中的 NAM 提高了沼泽鳗鱼的生长性能。它还降低了葡萄糖和脂质（包括葡萄糖、糖原、TG 和 NEFA）的含量以及肝脏中的脂肪积累，但增加了高密度脂蛋白胆固醇的含量。我们推测，NAM 通过降低 LPL、HL 和 LPS 等关键酶的活性来抑制肝脏中的脂质积累。脂肪酸谱分析显示，膳食 NAM 使肝脏中的 MUFA 和 PUFA（如棕榈油酸、油酸和二十碳五烯酸）含量显著增加，而 SFA（如肉豆蔻酸、硬脂酸和棕榈酸）含量减少。脂质体分析还表明，大多数差异脂质代谢物属于甘油磷脂和鞘磷脂，它们在胰岛素抵抗、脂肪细胞因子信号通路、胆固醇代谢、脂肪消化吸收、脂质和动脉粥样硬化、脂质细胞脂解调节等通路中富集。这些发现为沼泽鳗鱼对膳食 NAM 的代谢反应提供了科学依据和新见解，并为在沼泽鳗鱼生产中使用 NAM 作为饲料添加剂提供了基础知识。

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来源期刊

Aquaculture Reports Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

5.90

自引率

8.10%

发文量

469

审稿时长

77 days

期刊介绍： Aquaculture Reports will publish original research papers and reviews documenting outstanding science with a regional context and focus, answering the need for high quality information on novel species, systems and regions in emerging areas of aquaculture research and development, such as integrated multi-trophic aquaculture, urban aquaculture, ornamental, unfed aquaculture, offshore aquaculture and others. Papers having industry research as priority and encompassing product development research or current industry practice are encouraged.