Evolving Global Etiology of Hepatocellular Carcinoma (HCC): Insights and Trends for 2024

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
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Abstract

The epidemiology of HCC is changing all over the world and the incidence of HCC is expected to continue increasing over the next 30 years. The changes are in the predisposing factors. Hepatitis B and hepatitis C as predisposing etiologies are decreasing while NAFLD/MAFLD is increasing. The increase in MAFLD is so great that despite the decrease in hepatitis B and C, the overall incidence of HCC is increasing. HCC in persons below the age of 20 years has distinct characteristics different from that of HCC in adults. The changing etiology of hepatocellular carcinoma has implications for the early detection, prevention, the stage of HCC at time of detection and in the treatment of HCC. The extent of these changes and their significance are discussed.

全球肝细胞癌 (HCC) 病因不断演变:2024 年的洞察与趋势
全世界的 HCC 流行病学正在发生变化,预计在未来 30 年内,HCC 发病率将继续上升。这些变化体现在易感因素上。作为易感病因的乙型肝炎和丙型肝炎正在减少,而非酒精性脂肪肝/ MAFLD 正在增加。MAFLD 的增加幅度如此之大,以至于尽管乙型肝炎和丙型肝炎有所减少,但 HCC 的总体发病率却在增加。20 岁以下人群的 HCC 具有不同于成人 HCC 的明显特征。肝细胞癌病因的变化对早期检测、预防、检测时的肝细胞癌分期以及治疗肝细胞癌都有影响。本文讨论了这些变化的程度及其意义。
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来源期刊
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.90
自引率
16.70%
发文量
537
审稿时长
64 days
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