The multifaceted effects of mitochondria in kidney diseases

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-09-11 DOI:10.1016/j.mito.2024.101957

Jia-Le Xue , Jia-Ling Ji , Yan Zhou , Yao Zhang , Bi-Cheng Liu , Rui-Xia Ma , Zuo-Lin Li

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Abstract

Mitochondria serve as the primary site for aerobic respiration within cells, playing a crucial role in maintaining cellular homeostasis. To maintain homeostasis and meet the diverse demands of the cells, mitochondria have evolved intricate systems of quality control, mainly including mitochondrial dynamics, mitochondrial autophagy (mitophagy) and mitochondrial biogenesis. The kidney, characterized by its high energy requirements, is particularly abundant in mitochondria. Interestingly, the mitochondria display complex behaviors and functions. When the kidney is suffered from obstructive, ischemic, hypoxic, oxidative, or metabolic insults, the dysfunctional mitochondrial derived from the defects in the mitochondrial quality control system contribute to cellular inflammation, cellular senescence, and cell death, posing a threat to the kidney. However, in addition to causing injury to the kidney in several cases, mitochondria also exhibit protective effect on the kidney. In recent years, accumulating evidence indicated that mitochondria play a crucial role in adaptive repair following kidney diseases caused by various etiologies. In this article, we comprehensively reviewed the current understanding about the multifaceted effects of mitochondria on kidney diseases and their therapeutic potential.

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线粒体对肾脏疾病的多方面影响

线粒体是细胞内进行有氧呼吸的主要场所，在维持细胞平衡方面发挥着至关重要的作用。为了维持平衡和满足细胞的各种需求，线粒体进化出了复杂的质量控制系统，主要包括线粒体动力学、线粒体自噬（丝裂噬）和线粒体生物生成。肾脏的特点是能量需求高，因此线粒体特别丰富。有趣的是，线粒体具有复杂的行为和功能。当肾脏受到阻塞性、缺血性、缺氧性、氧化性或代谢性损伤时，线粒体质量控制系统缺陷导致的线粒体功能障碍会引发细胞炎症、细胞衰老和细胞死亡，从而对肾脏构成威胁。然而，线粒体除了在多种情况下对肾脏造成损伤外，还对肾脏有保护作用。近年来，越来越多的证据表明，线粒体在各种病因引起的肾脏疾病后的适应性修复中发挥着至关重要的作用。本文全面回顾了线粒体对肾脏疾病的多方面影响及其治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.