Sini San ameliorates lipid metabolism in hyperprolactinemia rat with liver-depression

IF 6.2 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Current Research in Food Science Pub Date : 2024-01-01 DOI:10.1016/j.crfs.2024.100853

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Abstract

Sini San (SNS) is used to treat liver depression and is applied in both food and herbal medicine. Hyperprolactinemia (HPRL) is a common endocrine disorder, and patients with HPRL are usually associated with depressive symptoms. However, whether SNS is effective in treating HPRL combined with liver depression and its underlying mechanisms are unknown. We applied network pharmacology and molecular docking to predict the mechanism of SNS for the treatment of liver-depressed HPRL. Therapeutic effects were validated in animal models and cells. Metabolomics was also used to evaluate the effect of SNS on liver-depressed HPRL. Network pharmacology and molecular docking analysis showed that AKT1, TNF and IL6 were the key targets, and SNS improved depressive behaviors, regulated sex hormone levels, and improved ovarian morphology. Combined network pharmacology and metabolomics analyses showed that SNS could act by regulating lipid metabolism. In addition, SNS significantly reduced the release of prolactin (PRL) in rat pituitary tumor MMQ cells. Overall, SNS can significantly treat HPRL liver depression at both animal and cellular levels, and effectively alleviate the related symptoms by regulating lipid metabolism. AKT1, TNF and IL6 may be key targets.

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四逆散可改善高泌乳素血症大鼠肝郁的脂质代谢

四逆散（SNS）用于治疗肝郁，在食品和中药中都有应用。高泌乳素血症（HPRL）是一种常见的内分泌疾病，HPRL 患者通常伴有抑郁症状。然而，SNS 是否能有效治疗 HPRL 合并肝郁及其内在机制尚不清楚。我们应用网络药理学和分子对接技术预测了SNS治疗肝郁型HPRL的机制。治疗效果在动物模型和细胞中得到了验证。代谢组学也被用来评估SNS对肝衰竭HPRL的影响。网络药理学和分子对接分析表明，AKT1、TNF和IL6是关键靶点，SNS能改善抑郁行为、调节性激素水平并改善卵巢形态。结合网络药理学和代谢组学分析表明，SNS 可通过调节脂质代谢发挥作用。此外，SNS还能明显减少大鼠垂体瘤MMQ细胞中催乳素（PRL）的释放。总之，SNS能在动物和细胞水平上显著治疗HPRL肝郁，并通过调节脂质代谢有效缓解相关症状。AKT1、TNF和IL6可能是关键靶点。

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来源期刊

Current Research in Food Science Agricultural and Biological Sciences-Food Science

CiteScore

7.40

自引率

3.20%

发文量

232

审稿时长

84 days

期刊介绍： Current Research in Food Science is an international peer-reviewed journal dedicated to advancing the breadth of knowledge in the field of food science. It serves as a platform for publishing original research articles and short communications that encompass a wide array of topics, including food chemistry, physics, microbiology, nutrition, nutraceuticals, process and package engineering, materials science, food sustainability, and food security. By covering these diverse areas, the journal aims to provide a comprehensive source of the latest scientific findings and technological advancements that are shaping the future of the food industry. The journal's scope is designed to address the multidisciplinary nature of food science, reflecting its commitment to promoting innovation and ensuring the safety and quality of the food supply.