Microwave irradiations toprepare novel 1,4-dihydropyridine, pyrimidoquinoline, triazoloquinazolinone,and imidazoquinazolinonedimer analogsand their antimicrobial performances

Abstract

The main intentof this work is to create novel 1,4-dihydropyridine, pyrimidoquinoline, triazoloquinazolinone, and imidazoquinazolinone dimers through microwave irradiation. These conformers were then evaluated for their capacity to impede the spread of bacteria in vitro against Salmonella typhi, Listeria monocytogenes, Candida albicans, Escherichia coli, and Staphylococcus aureus. The effective positive control substances involved vancomycin and ampicillin.With a MIC level between 57 to 147 mg/mL, substrates 3, 5, 7a, 7b, 9, and 12 shown the modest effectiveness towards inhibiting the growth both of bacteria and fungi. Compounds 13, 19, 15a, 15b, and 17 demonstrated excellent effectiveness in inhibiting the growth of the candida albicans fungus, with MIC level between 51 to 74 mg/mL, matching the positive control.With MIC level between 62 to 82 mg/mL, analogs 13, 19, 15a, and 15b showed outstanding activity against four different bacterial strains for growth suppression. Their activity was comparable to that of the positive control. Furthermore, compound 17 demonstrates remarkable growth inhibitory activity, outperforming the positive control in the 69–86 mg/mL MIC range. The dimer derivative triazoloquinazolinone 17 showed excellent antibacterial efficacy and showed tremendous promise for development into medicinal drugs in the future.