Multi-target anticancer activity of compounds isolated from galls of Pistacia chinensis subsp. integerrima: A mechanistic investigation

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-09-18 DOI:10.1016/j.phytol.2024.09.001

Abdur Rauf , Majid Khan , Arsalan Nizamani , Humaira Hussain , Zuneera Akram , Yahya S. Al-Awthan , Hassan A. Hemeg , Omar S. Bahattab , Giovanni Ribaudo

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引用次数: 0

Abstract

The usage of Pistacia chinensis subsp. integerrima (J.L. Stewart) Rech. f. and its extracts in traditional medicine is well-documented, since this plant is known for its anti-infective, antidiabetic and antioxidant properties. Additionally, recent studies described the antiproliferative activity of its extracts on cancer cell models. Nevertheless, the mechanisms of action underlying this biological effect still have to be fully elucidated. In this study, we focused our attention on the characterization of the bioactivity profile of the flavonoids spinacetin (1) and patuletin (2) and of the triterpene pistagremic acid (3) extracted from the galls of P. integerrima. The compounds were tested in vitro against aldose reductase and thymidine phosphorylase, two targets that are attracting growing attention in the field of drug discovery due to their involvement in metabolism regulation and angiogenesis. Computational studies were used to rationalize experimental data, and the results support the potential of spinacetin (1) as a promising bioactive multi-target anticancer agent.

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从Pistacia chinensis subsp：机理研究

Pistacia chinensis subsp. integerrima (J.L. Stewart) Rech. f.及其提取物在传统医学中的应用有据可查，因为这种植物以其抗感染、抗糖尿病和抗氧化特性而闻名。此外，最近的研究还描述了其提取物对癌细胞模型的抗增殖活性。然而，这种生物效应的作用机制仍有待全面阐明。在这项研究中，我们重点研究了从 P. integerrima 的虫瘿中提取的黄酮类化合物 spinacetin（1）和 patuletin（2）以及三萜类化合物 pistagremic acid（3）的生物活性特征。这些化合物针对醛糖还原酶和胸苷磷酸化酶进行了体外测试，这两个靶点由于参与新陈代谢调节和血管生成，在药物发现领域日益受到关注。计算研究被用来合理解释实验数据，其结果支持了旋覆花素 (1) 作为一种具有生物活性的多靶点抗癌剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.