Exosomes for skin treatment: Therapeutic and cosmetic applications

Nano TransMed Pub Date : 2024-09-12 DOI:10.1016/j.ntm.2024.100048

Harsha Sreeraj , R. AnuKiruthika , K.S. Tamilselvi , D. Subha

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Abstract

The therapeutic potential of exosomes, which are nano-sized extracellular vesicles derived from various cell types, have drawn substantial interest in the field of dermatology. Exosomes have distinctive capabilities, including facilitating intercellular communication, delivering bioactive molecules, and modulating immune responses, which make them promising candidates for skin regeneration, wound healing, and treating dermatological disorders. Specifically, exosomes derived from the stem cells of mesenchymal and adipose cells, have numerous applications in skin repair and regeneration. Exosomes also find expanded applications in treatments and therapies related to hair. Exosomes emit signals and growth factors that impact the activity of nearby epithelial cells, encouraging their growth, specialization, and the development of hair formations. This review explores the efficacy of topical and transdermal applications of exosomes in skin and hair and highlight the transformative potential of exosome-based therapies in dermatology and pave the way for future research and clinical applications.

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用于皮肤治疗的外泌体：治疗和美容应用

外泌体是来自各种细胞类型的纳米级细胞外囊泡，其治疗潜力已引起皮肤病学领域的极大兴趣。外泌体具有独特的功能，包括促进细胞间的交流、传递生物活性分子和调节免疫反应，因此有望用于皮肤再生、伤口愈合和治疗皮肤病。具体来说，从间充质细胞和脂肪细胞的干细胞中提取的外泌体在皮肤修复和再生方面有许多应用。外泌体在与毛发有关的治疗和疗法中也有广泛的应用。外泌体发出的信号和生长因子会影响附近上皮细胞的活动，促进它们的生长、特化和毛发的形成。这篇综述探讨了外泌体局部和透皮应用于皮肤和毛发的疗效，强调了基于外泌体的疗法在皮肤病学中的变革潜力，并为未来的研究和临床应用铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nano TransMed

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