The emerging roles of WOX genes in development and stress responses in woody plants

Abstract

Woody plants represent the world largest biomass which are actually developed from small amounts of stem cells. The programing and re-programing of these stem cells significantly affect the plastic development and environmental adaptation of woody plants. The WUSCHEL-related homeobox (WOX) genes constitute a family of plant-specific homeodomain transcription factors that perform key functions in plant development, including embryonic patterning, stem-cell maintenance, and organ formation. There also is emerging evidence supporting their participation in stress responses, although whether these functions are stem-cell-mediated is unknown. Past research has mainly focused on the WOX protein family in non-woody plants, such as Arabidopsis thaliana and Oryza sativa. The roles of WOX genes in woody plant stem cell regulation are less understood, partially due to their long life cycles, large physical sizes and challenges in obtaining transgenic trees. Recent advancements in transformation protocols in various tree species have begun to reveal the functions of WOXs in woody plants. Here, we summarize current understanding of WOXs in embryogenesis, organogenesis, and stress responses, highlighting an emerging molecular network centered on WOXs in woody plants.