Cardiometabolic biomarkers and comorbid metabolic syndrome in schizophrenia: A cross-sectional study of long-term clozapine/olanzapine users

IF 3.8 4区 医学 Q1 PSYCHIATRY
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引用次数: 0

Abstract

Objectives

Second-generation antipsychotics (SGAs) are often prescribed for patients with schizophrenia; however, SGAs are associated with the risk of metabolic syndrome (MetS). This study aimed to investigate the clinical and biochemical determinants of SGA-related MetS.

Methods

Patients with schizophrenia, aged between 20 and 65 years, and under clozapine or olanzapine treatment for at least 9 months, were recruited from a mental hospital. Demographic, comorbidity, clinical status, laboratory, and drug regimen data were collected through chart review. Circulating levels of adiponectin, thyroid hormone responsive protein, and fatty acid binding protein 4 (FABP4) were assayed. Multiple logistic regression was used to identify risk predictors of MetS.

Results

A total of 176 participants were enrolled, including 138 (78.4 %) clozapine users and 38 (21.6 %) olanzapine users. Forty-five (25.6 %) patients were classified as having MetS. The duration of clozapine or olanzapine usage was significantly shorter in those with MetS (p=0.026) than those without MetS. Patients with MetS had a significantly higher serum FABP4 concentration than their counterparts (22.5 ± 8.8 ng/mL vs. 15.7 ± 6.7 ng/mL, p<0.001), and also a significantly lower adiponectin level (6.9 ±4.0 mg/mL vs. 11.6 ± 6.6 mg/mL, p<0.001). A FABP4 level ≥ 16.98 ng/mL (OR: 24.16, 95 % CI: 7.47–78.09, p<0.001) was positively correlated with MetS, whereas serum adiponectin level was inversely correlated with MetS (OR: 0.7980, 95 % CI: 0.70–0.90, p<0.001).

Conclusions

Adiponectin, FABP4, and certain clinical covariates and comedications were highly correlated with SGA-related MetS. Further studies are required to investigate the underlying mechanisms.

精神分裂症患者的心脏代谢生物标志物和合并代谢综合征:一项针对氯氮平/奥氮平长期使用者的横断面研究
目的:第二代抗精神病药物(SGA)是精神分裂症患者的常用处方药;然而,SGA与代谢综合征(MetS)的风险有关。本研究旨在调查与 SGA 相关的代谢综合征的临床和生化决定因素。方法从一家精神病院招募年龄在 20 岁至 65 岁之间、接受氯氮平或奥氮平治疗至少 9 个月的精神分裂症患者。通过病历审查收集了患者的人口统计学、合并症、临床状态、实验室和用药方案等数据。检测了脂肪连素、甲状腺激素反应蛋白和脂肪酸结合蛋白 4 (FABP4) 的循环水平。结果 共有176名参与者参加了研究,其中包括138名氯氮平使用者(78.4%)和38名奥氮平使用者(21.6%)。45名患者(25.6%)被归类为 MetS 患者。有 MetS 的患者使用氯氮平或奥氮平的时间(p=0.026)明显短于无 MetS 的患者。MetS 患者的血清 FABP4 浓度明显高于同类患者(22.5 ± 8.8 纳克/毫升 vs. 15.7 ± 6.7 纳克/毫升,p<0.001),而脂肪连通素水平也明显低于同类患者(6.9 ± 4.0 毫克/毫升 vs. 11.6 ± 6.6 毫克/毫升,p<0.001)。FABP4水平≥16.98 ng/mL(OR:24.16,95 % CI:7.47-78.09,p<0.001)与MetS呈正相关,而血清脂肪连接蛋白水平与MetS呈反相关(OR:0.结论脂联素、FABP4、某些临床协变量和合并症与 SGA 相关 MetS 高度相关。需要进一步研究其潜在机制。
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来源期刊
Asian journal of psychiatry
Asian journal of psychiatry Medicine-Psychiatry and Mental Health
CiteScore
12.70
自引率
5.30%
发文量
297
审稿时长
35 days
期刊介绍: The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.
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