{"title":"Harnessing Leptolyngbya for antiproliferative and antimicrobial metabolites through lens of modern techniques: A review","authors":"","doi":"10.1016/j.algal.2024.103702","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer and antimicrobial resistance are pressing global health concerns, with cancer ranking as a foremost reason of death across the world, estimated to be about 10 million in 2020, while antimicrobial resistance (AMR) poses a significant threat, with projected deaths attributed to AMR set to exceed 10 million by 2050. Recent research has highlighted Actinomyces, Bacteroidetes, Proteobacteria, and Cyanobacteria as promising sources of therapeutic compounds. Among cyanobacteria, the genus <em>Leptolyngbya</em> has garnered relatively less attention. <em>Leptolyngbya</em> is a polyphyletic in nature and widely distributed across various ecosystems. Although over 140 species have been identified within this genus, its systematic position has only recently been clarified. <em>Leptolyngbya</em>'s diverse metabolite spectrum, including compounds with antioxidant, antimicrobial, and antiproliferative properties, as discussed in this review, makes it a valuable candidate for drug discovery. However, challenges in laboratory cultivation have hindered the identification of novel metabolites from <em>Leptolyngbya</em>, which would have been otherwise discovered. Hence, this article focuses on the antiproliferative and antimicrobial activities of the diverse genus <em>Leptolyngbya</em>, as well as the cutting-edge technologies that have the potential to expand the untapped metabolite spectrum of the genus.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Algal Research-Biomass Biofuels and Bioproducts","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221192642400314X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer and antimicrobial resistance are pressing global health concerns, with cancer ranking as a foremost reason of death across the world, estimated to be about 10 million in 2020, while antimicrobial resistance (AMR) poses a significant threat, with projected deaths attributed to AMR set to exceed 10 million by 2050. Recent research has highlighted Actinomyces, Bacteroidetes, Proteobacteria, and Cyanobacteria as promising sources of therapeutic compounds. Among cyanobacteria, the genus Leptolyngbya has garnered relatively less attention. Leptolyngbya is a polyphyletic in nature and widely distributed across various ecosystems. Although over 140 species have been identified within this genus, its systematic position has only recently been clarified. Leptolyngbya's diverse metabolite spectrum, including compounds with antioxidant, antimicrobial, and antiproliferative properties, as discussed in this review, makes it a valuable candidate for drug discovery. However, challenges in laboratory cultivation have hindered the identification of novel metabolites from Leptolyngbya, which would have been otherwise discovered. Hence, this article focuses on the antiproliferative and antimicrobial activities of the diverse genus Leptolyngbya, as well as the cutting-edge technologies that have the potential to expand the untapped metabolite spectrum of the genus.
期刊介绍:
Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment