Population Structure and Antimicrobial Resistance in Campylobacter jejuni and C. coli Isolated from Humans with Diarrhea and from Poultry, East Africa

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-09-17 DOI:10.3201/eid3010.231399

Nigel P. French, Kate M. Thomas, Nelson B. Amani, Jackie Benschop, Godfrey M. Bigogo, Sarah Cleaveland, Ahmed Fayaz, Ephrasia A. Hugho, Esron D. Karimuribo, Elizabeth Kasagama, Ruth Maganga, Matayo L. Melubo, Anne C. Midwinter, Blandina T. Mmbaga, Victor V. Mosha, Fadhili I. Mshana, Peninah Munyua, John B. Ochieng, Lynn Rogers, Emmanuel Sindiyo, Emanuel S. Swai, Jennifer R. Verani, Marc-Alain Widdowson, David A. Wilkinson, Rudovick R. Kazwala, John A. Crump, Ruth N. Zadoks

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引用次数: 0

Abstract

Campylobacteriosis and antimicrobial resistance (AMR) are global public health concerns. Africa is estimated to have the world’s highest incidence of campylobacteriosis and a relatively high prevalence of AMR in Campylobacter spp. from humans and animals. Few studies have compared Campylobacter spp. isolated from humans and poultry in Africa using whole-genome sequencing and antimicrobial susceptibility testing. We explored the population structure and AMR of 178 Campylobacter isolates from East Africa, 81 from patients with diarrhea in Kenya and 97 from 56 poultry samples in Tanzania, collected during 2006–2017. Sequence type diversity was high in both poultry and human isolates, and some sequence types were common. The estimated prevalence of multidrug resistance, defined as resistance to >3 antimicrobial classes, was higher in poultry isolates (40.9%, 95% credible interval 23.6%–59.4%) than in human isolates (2.5%, 95% credible interval 0.3%–6.8%), underlining the importance of antimicrobial stewardship in livestock systems.

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东非从腹泻患者和家禽中分离出的空肠弯曲杆菌和大肠杆菌的种群结构和抗菌药耐药性

弯曲杆菌病和抗菌药耐药性（AMR）是全球公共卫生关注的问题。据估计，非洲是世界上弯曲杆菌病发病率最高的地区，来自人类和动物的弯曲杆菌属的 AMR 感染率也相对较高。很少有研究利用全基因组测序和抗菌药敏感性测试对从非洲人类和家禽中分离的弯曲杆菌属进行比较。我们探索了东非 178 个弯曲杆菌分离物的种群结构和 AMR，其中 81 个来自肯尼亚的腹泻患者，97 个来自坦桑尼亚的 56 个家禽样本。家禽和人类分离物的序列类型多样性都很高，有些序列类型很常见。家禽分离物的多药耐药性（定义为对 3 种抗菌药物的耐药性）估计发生率（40.9%，95% 可信区间为 23.6%-59.4%）高于人类分离物（2.5%，95% 可信区间为 0.3%-6.8%），这凸显了抗菌药物管理在畜牧系统中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.