Early Introductions of Candida auris Detected by Wastewater Surveillance, Utah, USA, 2022–2023

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-09-17 DOI:10.3201/eid3010.240173

Jorge Chavez, Katherine Crank, Casey Barber, Daniel Gerrity, Thomas Iverson, Joshua Mongillo, Angela Weil, Linda Rider, Nathan Lacross, Kelly Oakeson, Alessandro Rossi

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Abstract

Candida auris is considered a nosocomial pathogen of high concern and is currently spreading across the United States. Infection control measures for C. auris focus mainly on healthcare facilities, yet transmission levels may already be significant in the community before outbreaks are detected in healthcare settings. Wastewater-based epidemiology (culture, quantitative PCR, and whole-genome sequencing) can potentially gauge pathogen transmission in the general population and lead to early detection of C. auris before it is detected in clinical cases. To learn more about the sensitivity and limitations of wastewater-based surveillance, we used wastewater-based methods to detect C. auris in a southern Utah jurisdiction with no known clinical cases before and after the documented transfer of colonized patients from bordering Nevada. Our study illustrates the potential of wastewater-based surveillance for being sufficiently sensitive to detect C. auris transmission during the early stages of introduction into a community.

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2022-2023 年美国犹他州通过废水监测发现的念珠菌早期引入情况

白色念珠菌被认为是一种值得高度关注的院内病原体，目前正在全美蔓延。针对白色念珠菌的感染控制措施主要集中在医疗机构，但在医疗机构发现疫情之前，社区中的传播水平可能已经很高。以废水为基础的流行病学（培养、定量 PCR 和全基因组测序）有可能衡量病原体在普通人群中的传播情况，并在临床病例中检测到 C. auris 之前对其进行早期检测。为了进一步了解基于废水的监测的灵敏度和局限性，我们使用基于废水的方法检测了犹他州南部的一个辖区内的 C. auris，该辖区内没有已知的临床病例，但在有记录的从内华达州接壤处转移来的定植患者之前和之后都发现了 C. auris。我们的研究表明，基于废水的监测具有足够的灵敏度，可以在C. auris传入社区的早期阶段检测到它的传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.