Adenosine A2B receptor activation regulates the balance between T helper 17 cells and regulatory T cells, and inhibits regulatory T cells exhaustion in experimental autoimmune myositis

IF 8.9 1区医学

Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2024-09-16 DOI:10.1002/jcsm.13581

Yueyuan Zhou, Limei Kang, Geng Yin, Leiyi Yang, Bo Chen, Binhan Liu, Xiaoyan Zhu, Qibing Xie

引用次数: 0

Abstract

Idiopathic inflammatory myopathy (IIM) is a systemic autoimmune disease characterized by skeletal muscle involvement. This study aimed to investigate the role of adenosine receptor signalling pathways in the development of experimental autoimmune myositis (EAM).

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激活腺苷 A2B 受体可调节 T 辅助 17 细胞和调节性 T 细胞之间的平衡，并抑制实验性自身免疫性肌炎中调节性 T 细胞的衰竭

特发性炎症性肌病（IIM）是一种以骨骼肌受累为特征的全身性自身免疫性疾病。本研究旨在探讨腺苷受体信号通路在实验性自身免疫性肌炎（EAM）发病过程中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine

自引率

12.40%

发文量

期刊介绍： The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.