Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-09-17 DOI:10.1002/alz.14244

Bing He, Ruiming Wu, Neel Sangani, Pradeep Varathan Pugalenthi, Alice Patania, Shannon L. Risacher, Kwangsik Nho, Liana G. Apostolova, Li Shen, Andrew J. Saykin, Jingwen Yan

引用次数: 0

Abstract

Alzheimer's disease (AD) initiates years prior to symptoms, underscoring the importance of early detection. While amyloid accumulation starts early, individuals with substantial amyloid burden may remain cognitively normal, implying that amyloid alone is not sufficient for early risk assessment.

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淀粉样蛋白成像与遗传学相结合，实现阿尔茨海默病早期风险分层

阿尔茨海默病（AD）在出现症状前数年就已开始发病，这凸显了早期检测的重要性。虽然淀粉样蛋白的积累开始得很早，但有大量淀粉样蛋白负担的人认知能力可能仍然正常，这意味着仅靠淀粉样蛋白不足以进行早期风险评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.

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