Lukas Gardner, John Rossi, Brock Armstrong, Mia Muse, Alex LaVeck, Melanie A. Blevins, Lingdi Zhang, Dr. Heide L. Ford, Dr. Rui Zhao, Dr. Xiang Wang
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Abstract
Protein-ligand docking simulation showing hydrogen bonding in green and Pi-Pi stacking in cyan between EYA2 and a novel inhibitor. Several new interactions are found in this study leading to >30-fold increase of potency relative to the previous lead analog. Many analogs in the series expanded our knowledge on beneficial interactions between the protein and potential inhibitors. This new series of inhibitors provides further insight into treatment of many cancer lines including Glioblastoma and Medulloblastoma. More details can be found in article 10.1002/cmdc.202400179 by Heide L. Ford, Rui Zhao, Xiang Wang, and co-workers.
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
Contents
ChemMedChem publishes an attractive mixture of:
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Book and Multimedia Reviews.
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