Shared Risk Volatile Organic Compounds Among Chronic Respiratory Diseases: Mediation Effects of System Inflammation

IF 4.3 2区环境科学与生态学 Q1 CONSTRUCTION & BUILDING TECHNOLOGY

Indoor air Pub Date : 2024-09-14 DOI:10.1155/2024/9416325

Mengya Xu, Wanlu Liu, Xinyu Zhu, Baihao Lin, Yuyu Zheng, Yansen Bai

{"title":"Shared Risk Volatile Organic Compounds Among Chronic Respiratory Diseases: Mediation Effects of System Inflammation","authors":"Mengya Xu, Wanlu Liu, Xinyu Zhu, Baihao Lin, Yuyu Zheng, Yansen Bai","doi":"10.1155/2024/9416325","DOIUrl":null,"url":null,"abstract":"Background: Volatile organic compounds (VOCs) are indoor and outdoor air pollution, but the VOCs that were shared across chronic respiratory diseases (CRDs) remained unknown. Meanwhile, the mediating roles of system inflammation need to be further explored.Methods: This study included 9114 adults based on the National Health and Nutrition Examination Survey (NHANES) 2005–2006 and 2011–2018. Internal exposure levels of 14 urinary metabolites of VOC (mVOCs), blood cell count–derived inflammatory biomarkers, and prevalent CRDs, including asthma, chronic bronchitis, and emphysema, were assessed and collected. Associations of single- and multiple-mVOCs with CRDs were assessed by using logistic regression and quantile-based g-computation (QGcomp) methods to select the key and shared mVOCs among CRDs. Mediation effects of system inflammation on mVOC-CRD associations were further evaluated by causal mediation analysis.Results: Increased levels of total 14 mVOCs were associated with increased risk of chronic bronchitis (OR = 1.62, 95% CI: 1.37–1.91), emphysema (OR = 1.73, 95% CI: 1.27–2.35), and both conditions combined (defined as chronic obstructive pulmonary disease, COPD) (OR = 1.61, 95% CI: 1.37–1.88), but not for asthma (OR = 1.07, 95% CI: 0.94–1.21). In both single- and multiple-mVOC exposure models, 8 key mVOCs were COPD associated, including 6 mVOCs (34MHA, AMCC, CEMA, DHBMA, 3HPMA, and MHBMA3) and 5 mVOCs (34MHA, CYMA, 3HPMA, MA, and MHBMA3) that were associated with increased risk of chronic bronchitis and emphysema, respectively. Particularly, 34MHA, 3HPMA, and MHBMA3 were shared risk factors across chronic bronchitis, emphysema, and COPD. Neutrophils mediated the associations of three shared mVOCs with chronic bronchitis (by 5.20%, 7.80%, 6.30%), emphysema (by 6.90%, 9.30%, 9.70%), and COPD (by 5.80%, 8.90%, 7.70%).Conclusions: These findings provide valuable insights into the shared risk mVOCs and mediating roles of neutrophils involved in the pathogenesis of CRDs, which can be useful in developing more effective prevention and intervention strategies for CRDs.","PeriodicalId":13529,"journal":{"name":"Indoor air","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9416325","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indoor air","FirstCategoryId":"93","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/9416325","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CONSTRUCTION & BUILDING TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Volatile organic compounds (VOCs) are indoor and outdoor air pollution, but the VOCs that were shared across chronic respiratory diseases (CRDs) remained unknown. Meanwhile, the mediating roles of system inflammation need to be further explored.

Methods: This study included 9114 adults based on the National Health and Nutrition Examination Survey (NHANES) 2005–2006 and 2011–2018. Internal exposure levels of 14 urinary metabolites of VOC (mVOCs), blood cell count–derived inflammatory biomarkers, and prevalent CRDs, including asthma, chronic bronchitis, and emphysema, were assessed and collected. Associations of single- and multiple-mVOCs with CRDs were assessed by using logistic regression and quantile-based g-computation (QGcomp) methods to select the key and shared mVOCs among CRDs. Mediation effects of system inflammation on mVOC-CRD associations were further evaluated by causal mediation analysis.

Results: Increased levels of total 14 mVOCs were associated with increased risk of chronic bronchitis (OR = 1.62, 95% CI: 1.37–1.91), emphysema (OR = 1.73, 95% CI: 1.27–2.35), and both conditions combined (defined as chronic obstructive pulmonary disease, COPD) (OR = 1.61, 95% CI: 1.37–1.88), but not for asthma (OR = 1.07, 95% CI: 0.94–1.21). In both single- and multiple-mVOC exposure models, 8 key mVOCs were COPD associated, including 6 mVOCs (34MHA, AMCC, CEMA, DHBMA, 3HPMA, and MHBMA3) and 5 mVOCs (34MHA, CYMA, 3HPMA, MA, and MHBMA3) that were associated with increased risk of chronic bronchitis and emphysema, respectively. Particularly, 34MHA, 3HPMA, and MHBMA3 were shared risk factors across chronic bronchitis, emphysema, and COPD. Neutrophils mediated the associations of three shared mVOCs with chronic bronchitis (by 5.20%, 7.80%, 6.30%), emphysema (by 6.90%, 9.30%, 9.70%), and COPD (by 5.80%, 8.90%, 7.70%).

Conclusions: These findings provide valuable insights into the shared risk mVOCs and mediating roles of neutrophils involved in the pathogenesis of CRDs, which can be useful in developing more effective prevention and intervention strategies for CRDs.

Abstract Image

查看原文本刊更多论文

慢性呼吸系统疾病中的共同风险挥发性有机化合物：系统炎症的中介效应

背景：挥发性有机化合物（VOCs）是室内和室外的空气污染，但慢性呼吸系统疾病（CRDs）共有的VOCs仍然未知。同时，系统炎症的中介作用也有待进一步探讨：本研究根据 2005-2006 年和 2011-2018 年美国国家健康与营养调查（NHANES）纳入了 9114 名成年人。评估并收集了 14 种尿液挥发性有机化合物代谢物（mVOCs）的内部暴露水平、源自血细胞计数的炎症生物标志物以及包括哮喘、慢性支气管炎和肺气肿在内的普遍 CRDs。通过使用逻辑回归和基于量级的g计算（QGcomp）方法评估了单个和多个mVOCs与CRDs的关联，从而筛选出CRDs中的关键和共有mVOCs。通过因果中介分析进一步评估了系统炎症对 mVOC 与 CRD 关联的中介效应：结果：总计 14 种 mVOC 水平的升高与慢性支气管炎（OR = 1.62，95% CI：1.37-1.91）、肺气肿（OR = 1.73，95% CI：1.27-2.35）以及这两种疾病（定义为慢性阻塞性肺疾病，COPD）（OR = 1.61，95% CI：1.37-1.88）风险的升高有关，但与哮喘（OR = 1.07，95% CI：0.94-1.21）无关。在单一和多重 mVOC 暴露模型中，有 8 种关键 mVOC 与慢性阻塞性肺病相关，其中 6 种 mVOC（34MHA、AMCC、CEMA、DHBMA、3HPMA 和 MHBMA3）和 5 种 mVOC（34MHA、CYMA、3HPMA、MA 和 MHBMA3）分别与慢性支气管炎和肺气肿风险增加相关。特别是，34MHA、3HPMA 和 MHBMA3 是慢性支气管炎、肺气肿和慢性阻塞性肺病的共同风险因素。中性粒细胞介导了三种共有 mVOC 与慢性支气管炎（5.20%、7.80%、6.30%）、肺气肿（6.90%、9.30%、9.70%）和慢性阻塞性肺病（5.80%、8.90%、7.70%）的关联：这些研究结果为了解中性粒细胞参与 CRD 发病机制的共同风险 mVOCs 和中介作用提供了有价值的见解，有助于制定更有效的 CRD 预防和干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indoor air 环境科学-工程：环境

CiteScore

10.80

自引率

10.30%

发文量

175

审稿时长

3 months

期刊介绍： The quality of the environment within buildings is a topic of major importance for public health. Indoor Air provides a location for reporting original research results in the broad area defined by the indoor environment of non-industrial buildings. An international journal with multidisciplinary content, Indoor Air publishes papers reflecting the broad categories of interest in this field: health effects; thermal comfort; monitoring and modelling; source characterization; ventilation and other environmental control techniques. The research results present the basic information to allow designers, building owners, and operators to provide a healthy and comfortable environment for building occupants, as well as giving medical practitioners information on how to deal with illnesses related to the indoor environment.