Androgenic Alopecia Is Associated With More Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

LUTS: Lower Urinary Tract Symptoms Pub Date : 2024-09-12 DOI:10.1111/luts.12531

Yasar Pazir, Mustafa Kadihasanoglu

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引用次数: 0

Abstract

Objectives

To evaluate the possible association between androgenic alopecia (AGA) and lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

Methods

A total of 148 patients aged over 45 with LUTS secondary to BPH were prospectively enrolled in this study. According to the Norwood–Hamilton classification, the patients were divided into two groups: AGA (n = 69) and non-AGA (n = 79). In addition, the cases of AGA were categorized as vertex (n = 39) and frontal baldness (n = 30). The International Prostate Symptom Score (IPSS), uroflowmetry parameters, prostate volume, serum total testosterone (TT), and free and total prostate-specific antigen concentrations of all patients were assessed and compared between the groups. Correlations between the AGA grade and other variables were also investigated.

Results

The serum TT level (354 ± 97.1 vs. 308.6 ± 73.1 ng/dL, p = 0.01), total IPSS (16.1 ± 8.1 vs. 13.4 ± 7.7, p = 0.04), IPSS storage subscore (IPSS-S) (7.1 ± 3.5 vs. 5.8 ± 3.6, p = 0.03), and number of nocturia episodes (2.5 ± 1.4 vs. 1.8 ± 1.4, p < 0.01) were significantly higher in the AGA group than in the non-AGA group. There were no significant differences in any of the parameters between the patients with vertex and frontal baldness. The AGA grade showed a significant positive correlation with the TT level (r = 0.407, p = 0.003), IPSS-S (r = 0.164, p = 0.04), and number of nocturia episodes (r = 0.203, p = 0.015).

Conclusions

This study demonstrated that among patients with LUTS, those with AGA had worse symptoms and higher TT levels compared with those without AGA of similar age. Furthermore, the AGA grade was positively correlated with the TT level and storage symptoms.

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雄激素性脱发与继发于良性前列腺增生症的更严重下尿路症状有关

目的评估雄激素性脱发（AGA）与继发于良性前列腺增生症（BPH）的下尿路症状（LUTS）之间可能存在的关联。方法本研究前瞻性地纳入了 148 名 45 岁以上、继发于良性前列腺增生症的下尿路症状患者。根据诺伍德-汉密尔顿分类法，患者被分为两组：AGA组（69人）和非AGA组（79人）。此外，AGA病例还分为顶秃病例（39人）和额秃病例（30人）。对所有患者的国际前列腺症状评分（IPSS）、尿流率参数、前列腺体积、血清总睾酮（TT）、游离和总前列腺特异性抗原浓度进行评估，并在各组之间进行比较。此外，还研究了 AGA 分级与其他变量之间的相关性。结果血清 TT 水平（354 ± 97.1 vs. 308.6 ± 73.1 ng/dL，p = 0.01）、总 IPSS（16.1 ± 8.1 vs. 13.4 ± 7.7，p = 0.04）、IPSS 存储子分数（IPSS-S）（7.1 ± 3.5 vs. 5.8 ± 3.6, p = 0.03）和夜尿次数（2.5 ± 1.4 vs. 1.8 ± 1.4, p < 0.01）在 AGA 组明显高于非 AGA 组。顶秃和额秃患者的任何参数均无明显差异。AGA 等级与 TT 水平（r = 0.407，p = 0.003）、IPSS-S（r = 0.164，p = 0.04）和夜尿次数（r = 0.203，p = 0.015）呈显著正相关。结论本研究表明，在 LUTS 患者中，与年龄相仿的非 AGA 患者相比，AGA 患者的症状更严重，TT 水平更高。此外，AGA 等级与 TT 水平和贮积症状呈正相关。

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来源期刊

LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.