Compressive properties and biocompatibility of additively manufactured lattice structures by using bioactive materials

IF 5.7 1区工程技术 Q1 ENGINEERING, CIVIL

Thin-Walled Structures Pub Date : 2024-09-13 DOI:10.1016/j.tws.2024.112469

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引用次数: 0

Abstract

Porous bioactive materials were widely used in orthopedic implant fields because of their excellent mechanical properties and porous spaces. However, most porous types are predominantly stacked in two-dimensional configurations, which significantly limits their mechanical property range and adversely affects the modulus matching between the porous implants and surrounding bone tissues. Hence, various lattice structures were prepared using 3D printing technology with bioactive materials, and characterized by mechanical and biological tests. Numerical simulations were conducted to analyze the effect of relative density and geometric parameters on the equivalent compressive properties of the lattice structures. The results showed that the lattice structure exhibited a broad elastic modulus range, which can be adjusted to align with the mechanical properties of human cortical and cancellous bones, thereby helping to mitigate stress shielding in orthopedic implants. The biocompatibility of the 3D-printed solid materials was assessed in vitro using a cell counting assay kit-8 (CCK-8). The results indicated that poly-ether-ether-ketone (PEEK), carbon fiber reinforced PEEK (CFR/PEEK), nylon, and titanium (Ti) alloy all exhibited good biocompatibility, with no significant differences observed among the four materials. This study further enhances the understanding of bioactive lattice structures in the biomedical field and offers new possibilities for orthopedic repair.

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使用生物活性材料加成制造晶格结构的压缩特性和生物相容性

多孔生物活性材料因其优异的机械性能和多孔空间而被广泛应用于骨科植入物领域。然而，大多数多孔类型主要以二维构型堆叠，这大大限制了其机械性能范围，并对多孔植入物与周围骨组织之间的模量匹配产生不利影响。因此，我们利用生物活性材料的三维打印技术制备了各种晶格结构，并通过机械和生物测试对其进行了表征。数值模拟分析了相对密度和几何参数对晶格结构等效抗压性能的影响。结果表明，晶格结构的弹性模量范围很宽，可根据人体皮质骨和松质骨的机械性能进行调整，从而有助于减轻骨科植入物的应力屏蔽。使用细胞计数检测试剂盒-8（CCK-8）对三维打印固体材料的生物相容性进行了体外评估。结果表明，聚醚醚酮（PEEK）、碳纤维增强 PEEK（CFR/PEEK）、尼龙和钛（Ti）合金都表现出良好的生物相容性，四种材料之间没有明显差异。这项研究进一步加深了生物医学领域对生物活性晶格结构的理解，为骨科修复提供了新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thin-Walled Structures 工程技术-工程：土木

CiteScore

9.60

自引率

20.30%

发文量

801

审稿时长

66 days

期刊介绍： Thin-walled structures comprises an important and growing proportion of engineering construction with areas of application becoming increasingly diverse, ranging from aircraft, bridges, ships and oil rigs to storage vessels, industrial buildings and warehouses. Many factors, including cost and weight economy, new materials and processes and the growth of powerful methods of analysis have contributed to this growth, and led to the need for a journal which concentrates specifically on structures in which problems arise due to the thinness of the walls. This field includes cold– formed sections, plate and shell structures, reinforced plastics structures and aluminium structures, and is of importance in many branches of engineering. The primary criterion for consideration of papers in Thin–Walled Structures is that they must be concerned with thin–walled structures or the basic problems inherent in thin–walled structures. Provided this criterion is satisfied no restriction is placed on the type of construction, material or field of application. Papers on theory, experiment, design, etc., are published and it is expected that many papers will contain aspects of all three.

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