tsRNA modifications: An emerging layer of biological regulation in disease

IF 11.4 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Yaomin Liang, Ding Ji, Xiaoling Ying, Renqiang Ma, Weidong Ji
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引用次数: 0

Abstract

Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an important and increasingly valued type of small non-coding RNA (sncRNA). The investigation of tRNA and tsRNA modification crosswalks has not only provided novel insights into the information and functions of tsRNA, but has also expanded the diversity and complexity of the tsRNA biological regulation network. Comparing with other sncRNAs, tsRNA biogenesis show obvious correlation with RNA modifications from mature tRNA and harbor various tRNA modifications. In this review, we aim to present the current aspect of tsRNA modifications and that modified tsRNA shape different regulatory mechanisms in physiological and pathological processes. Strategies for studying tsRNA mechanisms include its specific generation and functional effects induced by sequence/RNA modification/secondary structure. tsRNAs could harbor more than one tRNA modifications such as 5-methylcytosine (mC), N1-methyladenosine (mA), pseudouridine (Ψ) and N7-methylguanosine (mG). This review consolidates the current knowledge of tRNA modification regulating tsRNA biogenesis, outlines the functional roles of various modified tsRNA and highlights their specific contributions in various disease pathogenesis. Therefore, the improvement of tsRNA modification detection technology and the introduction of experimental methods of tsRNA modification are conducive to further broadening the understanding of tsRNA function at the level of RNA modification.
tsRNA 修饰:疾病中新出现的生物调控层
转运核糖核酸(tRNA)衍生的小核糖核酸(tsRNA)是一种重要的非编码小核糖核酸(sncRNA),而且越来越受到重视。对tRNA和tsRNA修饰交叉途径的研究不仅为tsRNA的信息和功能提供了新的见解,而且拓展了tsRNA生物调控网络的多样性和复杂性。与其他 sncRNA 相比,tsRNA 的生物发生与成熟 tRNA 的 RNA 修饰有着明显的相关性,并蕴藏着各种 tRNA 修饰。在这篇综述中,我们旨在介绍tsRNA修饰的现状,以及修饰后的tsRNA在生理和病理过程中形成的不同调控机制。研究 tsRNA 机制的策略包括其特异性生成和由序列/RNA 修饰/二级结构诱导的功能效应。tsRNA 可携带不止一种 tRNA 修饰,如 5-甲基胞嘧啶(mC)、N1-甲基腺苷(mA)、假尿苷(Ψ)和 N7-甲基鸟苷(mG)。这篇综述整合了目前关于调控 tsRNA 生物发生的 tRNA 修饰的知识,概述了各种修饰 tsRNA 的功能作用,并强调了它们在各种疾病发病机制中的特殊作用。因此,tsRNA修饰检测技术的提高和tsRNA修饰实验方法的引入,有利于进一步拓宽对tsRNA在RNA修饰水平功能的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
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