Research Progress on the Role of Cartilage Endplate in Intervertebral Disc Degeneration

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2024-09-12 DOI:10.1002/cbf.4118

Zhong Ma, Xin Liu, Mingtao Zhang, Zuolong Wu, Xianxu Zhang, Shicheng Li, Jiangdong An, Zhiqiang Luo

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Abstract

Low back pain significantly impacts individuals' quality of life, with intervertebral disc degeneration (IDD) being a primary contributor to this condition. Currently, IDD treatment primarily focuses on symptom management and does not achieve a definitive cure. The cartilage endplate (CEP), a crucial nutrient-supplying tissue of the intervertebral disc, plays a pivotal role in disc degeneration. This review examines the mechanisms underlying CEP degeneration, summarizing recent advancements in understanding the structure and function of CEP, the involvement of various signaling pathways, and the roles of cartilage endplate stem cells (CESCs) and exosomes (Exos) in this process. The aim of this review is to provide a comprehensive reference for future research on CEP. Despite progress in understanding the role of CEP in IDD, the mechanisms underlying CEP degeneration remain incompletely elucidated. Future research poses significant challenges, necessitating further investigations to elucidate the complexities of CEP.

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软骨终板在椎间盘退变中的作用研究进展

腰背痛严重影响着人们的生活质量，而椎间盘退变（IDD）是导致腰背痛的主要原因。目前，IDD 的治疗主要集中在症状控制上，并不能达到彻底治愈的目的。软骨终板（CEP）是椎间盘的重要营养供应组织，在椎间盘退变中起着关键作用。本综述探讨了CEP退化的内在机制，总结了在了解CEP的结构和功能、各种信号通路的参与以及软骨终板干细胞（CESCs）和外泌体（Exos）在这一过程中的作用等方面的最新进展。本综述旨在为未来的 CEP 研究提供全面的参考。尽管在了解 CEP 在 IDD 中的作用方面取得了进展，但 CEP 退化的内在机制仍未完全阐明。未来的研究面临着巨大的挑战，有必要开展进一步的调查，以阐明 CEP 的复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.