{"title":"Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy","authors":"","doi":"10.1016/j.ccr.2024.216207","DOIUrl":null,"url":null,"abstract":"<div><p>Hydrogel-integrated nanostructures offer a novel approach to cancer therapy by combining hydrogels' biocompatibility and tunable drug release with nanotechnology. These nanoplatforms enhance treatment precision and efficacy while minimizing side effects, providing a sophisticated and targeted delivery system. This comprehensive review explores synergistic cancer therapies utilizing hydrogel-integrated nanoplatforms, which employ dual strategies to enhance their anticancer efficacy. These strategies include chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy, radiotherapy (RT), gene therapy (GT), and magnetic hyperthermia therapy (MHT). Such platforms have the potential to overcome multidrug-resistant cancers, pioneer innovative treatment modalities, and improve patient survival rates compared to monotherapies. However, challenges such as scalability, regulatory approval, optimizing drug release kinetics, and addressing potential toxicity concerns remain, which are critical for assessing their long-term effects and clinical applicability.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854524005538","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Hydrogel-integrated nanostructures offer a novel approach to cancer therapy by combining hydrogels' biocompatibility and tunable drug release with nanotechnology. These nanoplatforms enhance treatment precision and efficacy while minimizing side effects, providing a sophisticated and targeted delivery system. This comprehensive review explores synergistic cancer therapies utilizing hydrogel-integrated nanoplatforms, which employ dual strategies to enhance their anticancer efficacy. These strategies include chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy, radiotherapy (RT), gene therapy (GT), and magnetic hyperthermia therapy (MHT). Such platforms have the potential to overcome multidrug-resistant cancers, pioneer innovative treatment modalities, and improve patient survival rates compared to monotherapies. However, challenges such as scalability, regulatory approval, optimizing drug release kinetics, and addressing potential toxicity concerns remain, which are critical for assessing their long-term effects and clinical applicability.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.