Thyroid lesions in a population of domestic cats submitted to necropsy without clinical suspicion of thyroid disease

IF 0.8 4区 农林科学 Q4 PATHOLOGY
Alana P. Herbichi, Douglas M. Lorenzetti, Matheus Y. dos Santos, Gabriela Hartmann, Rafael A. Fighera, Mariana M. Flores
{"title":"Thyroid lesions in a population of domestic cats submitted to necropsy without clinical suspicion of thyroid disease","authors":"Alana P. Herbichi,&nbsp;Douglas M. Lorenzetti,&nbsp;Matheus Y. dos Santos,&nbsp;Gabriela Hartmann,&nbsp;Rafael A. Fighera,&nbsp;Mariana M. Flores","doi":"10.1016/j.jcpa.2024.08.002","DOIUrl":null,"url":null,"abstract":"<div><p>Although hyperthyroidism is the most common endocrine disorder in elderly cats, systematic studies investigating the prevalence of thyroid lesions in feline animals are scarce. Our objective was to evaluate morphological changes in the thyroid glands of 61 cats submitted to necropsy without clinical suspicion of hyperthyroidism. Thirteen (13/61 [21.3%]) cats had thyroid enlargement and 54/61 (88.5%) had some histological thyroid changes. Proliferative lesions were histologically seen in 33/61 (54%) cats while non-proliferative lesions were observed in 48/61 (78.7%) cats. Thyroid hyperplasia (18/33 [54.5%]) and cystic adenoma (6/33 [18.2%]) were the most prevalent proliferative changes and lesions with little or no clinical significance (37/61 [60.6%]), degenerative (31/61 [50.8%]) and inflammatory changes (12/61 [19.7%]) were the most common non-proliferative changes. Among cats with proliferative lesions, 16/33 (48.4%) had a proliferation grade ≥A4, a grade previously associated with clinical hyperthyroidism. Although the cats from this study did not have any clinical diagnosis of thyroid disease, it is possible that one or more had some degree of clinically unnoticed thyroid dysfunction. The high prevalence of follicular lesions in this study highlights the importance of a more careful clinical and pathological investigation regarding thyroid diseases in mature and elderly cats.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 1-9"},"PeriodicalIF":0.8000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Comparative Pathology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021997524002950","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Although hyperthyroidism is the most common endocrine disorder in elderly cats, systematic studies investigating the prevalence of thyroid lesions in feline animals are scarce. Our objective was to evaluate morphological changes in the thyroid glands of 61 cats submitted to necropsy without clinical suspicion of hyperthyroidism. Thirteen (13/61 [21.3%]) cats had thyroid enlargement and 54/61 (88.5%) had some histological thyroid changes. Proliferative lesions were histologically seen in 33/61 (54%) cats while non-proliferative lesions were observed in 48/61 (78.7%) cats. Thyroid hyperplasia (18/33 [54.5%]) and cystic adenoma (6/33 [18.2%]) were the most prevalent proliferative changes and lesions with little or no clinical significance (37/61 [60.6%]), degenerative (31/61 [50.8%]) and inflammatory changes (12/61 [19.7%]) were the most common non-proliferative changes. Among cats with proliferative lesions, 16/33 (48.4%) had a proliferation grade ≥A4, a grade previously associated with clinical hyperthyroidism. Although the cats from this study did not have any clinical diagnosis of thyroid disease, it is possible that one or more had some degree of clinically unnoticed thyroid dysfunction. The high prevalence of follicular lesions in this study highlights the importance of a more careful clinical and pathological investigation regarding thyroid diseases in mature and elderly cats.

在没有临床怀疑甲状腺疾病的情况下接受尸体解剖的家猫群体中发现甲状腺病变
尽管甲状腺机能亢进症是老年猫最常见的内分泌疾病,但对猫科动物甲状腺病变患病率的系统研究却很少。我们的目的是评估61只接受尸检但未临床怀疑甲状腺功能亢进的猫的甲状腺形态变化。13只(13/61 [21.3%])猫有甲状腺肿大,54/61(88.5%)有一些甲状腺组织学变化。从组织学角度看,33/61(54%)只猫出现了增生性病变,48/61(78.7%)只猫出现了非增生性病变。甲状腺增生(18/33 [54.5%])和囊性腺瘤(6/33 [18.2%])是最常见的增生性病变,而几乎没有临床意义的病变(37/61 [60.6%])、退行性病变(31/61 [50.8%])和炎症性病变(12/61 [19.7%])是最常见的非增生性病变。在有增生性病变的猫中,16/33(48.4%)的增生等级≥A4,这一等级以前与临床甲状腺机能亢进症有关。虽然这项研究中的猫没有任何甲状腺疾病的临床诊断,但可能有一只或更多的猫存在某种程度的临床未发现的甲状腺功能障碍。本研究中滤泡性病变的高发率凸显了对成熟猫和老年猫的甲状腺疾病进行更仔细的临床和病理检查的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.60
自引率
0.00%
发文量
208
审稿时长
50 days
期刊介绍: The Journal of Comparative Pathology is an International, English language, peer-reviewed journal which publishes full length articles, short papers and review articles of high scientific quality on all aspects of the pathology of the diseases of domesticated and other vertebrate animals. Articles on human diseases are also included if they present features of special interest when viewed against the general background of vertebrate pathology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信