Electronic Nose Analysis of Exhaled Breath Volatile Organic Compound Profiles during Normoxia, Hypoxia, and Hyperoxia

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2024-09-13 DOI:10.3390/molecules29184358

Pasquale Tondo, Giulia Scioscia, Marcin Di Marco, Vitaliano Nicola Quaranta, Terence Campanino, Giuseppe Palmieri, Andrea Portacci, Andrea Santamato, Donato Lacedonia, Giovanna Elisiana Carpagnano, Silvano Dragonieri

引用次数: 0

Abstract

This study investigates volatile organic compound (VOC) profiles in the exhaled breath of normal subjects under different oxygenation conditions—normoxia (FiO2 21%), hypoxia (FiO2 11%), and hyperoxia (FiO2 35%)—using an electronic nose (e-nose). We aim to identify significant differences in VOC profiles among the three conditions utilizing principal component analysis (PCA) and canonical discriminant analysis (CDA). Our results indicate distinct VOC patterns corresponding to each oxygenation state, demonstrating the potential of e-nose technology in detecting physiological changes in breath composition (cross-validated accuracy values: FiO2 21% vs. FiO2 11% = 63%, FiO2 11% vs. FiO2 35% = 65%, FiO2 21% vs. FiO2 35% = 71%, and p < 0.05 for all). This research underscores the viability of breathomics in the non-invasive monitoring and diagnostics of various respiratory and systemic conditions.

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电子鼻分析正常缺氧、缺氧和高氧时呼出气体中挥发性有机化合物的概况

本研究利用电子鼻（e-nose）研究了正常人在不同氧合条件下--缺氧（FiO2 21%）、缺氧（FiO2 11%）和高氧（FiO2 35%）--呼出气体中挥发性有机化合物（VOC）的特征。我们的目的是利用主成分分析（PCA）和典型判别分析（CDA）找出三种条件下 VOC 特征的显著差异。我们的研究结果表明，每种氧合状态都对应着不同的挥发性有机化合物模式，这证明了电子鼻技术在检测呼吸成分生理变化方面的潜力（交叉验证的准确度值：FiO2 21% vs. FiO2 11% = 63%，FiO2 11% vs. FiO2 35% = 65%，FiO2 21% vs. FiO2 35% = 71%，P < 0.05）。这项研究强调了呼吸组学在各种呼吸系统和全身疾病的无创监测和诊断中的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.

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