Cavity-Size-Adjustable Macrocycles as a Novel Vaccine Adjuvant for Tumor Immunotherapy

IF 8.7 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-08-20 DOI:10.1021/acsmaterialslett.4c00442

Yuna Shang, Fan Zhang, Zhongyan Wang, Hongjing Luo, Hui Liu, Jiayi Lu, Yinyin Feng, Jiayu Wang, Aifeng Liu, Chao Zhang, Bin Li, Junyi Chen, Ming Dong, Chunju Li

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Abstract

In this study, we constructed a macrocycle-based vaccine system driving antigen accumulation in lymph nodes. The capabilities of antigen delivery and immune activation as vaccine adjuvants are based on three positively charged water-soluble biphen[3]arenes (WP 3s: WTP3, WQP3, and WPP3) with different cavity sizes were synchronously investigated. Compared to the OVA group, WTP3, WQP3, and WPP3 exhibited a significant increase in the IgG antibody titer by ∼ 2.3 × 10²-, 2.7 × 10³-, and 7.6 × 10³-fold, respectively. Therefore, we are convinced that biphen[3]arenes with larger cavity sizes not only demonstrate enhanced protein loading and binding capacity in vitro, but also manifest prolonged antigen retention time and heightened immune activation ability in vivo. To the best of our knowledge, this study represents the initial exploration of the impact of macrocyclic cavity sizes on the efficiency of antigen delivery as well as its potential influence on immune response capabilities.

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空腔大小可调的大环作为肿瘤免疫疗法的新型疫苗佐剂

在这项研究中，我们构建了一种基于大循环的疫苗系统，该系统可促使抗原在淋巴结中积累。我们同步研究了三种带正电荷的水溶性双酚[3]烷（WP 3s：WTP3、WQP3 和 WPP3）作为疫苗佐剂的抗原递送和免疫激活能力。与 OVA 组相比，WTP3、WQP3 和 WPP3 的 IgG 抗体滴度分别显著增加了 2.3 × 102 倍、2.7 × 103 倍和 7.6 × 103 倍。因此，我们确信，具有较大空腔尺寸的双酚[3]炔不仅在体外表现出更强的蛋白质负载和结合能力，而且在体内也表现出更长的抗原保留时间和更强的免疫激活能力。据我们所知，这项研究首次探索了大环空腔尺寸对抗原递送效率的影响及其对免疫反应能力的潜在影响。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.