Assessment of fused deposition modeling (FDM) parameters for fabrication of solid and hollow microneedles using polylactic acid (PLA)

IF 3.1 4区工程技术 Q2 POLYMER SCIENCE

Polymers for Advanced Technologies Pub Date : 2024-08-22 DOI:10.1002/pat.6548

Marie‐Carole Kouassi, Achraf Kallel, Abir Ben Abdallah, Samia Nouira, Sébastien Ballut, Joseph Fitoussi, Mohammadali Shirinbayan

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引用次数: 0

Abstract

This paper investigates the limits of a Fused Deposition Modeling (FDM) process for the fabrication of solid and hollow microneedle patches. Polylactic acid (PLA), a biodegradable and biocompatible polymer, was used as the printing material. For solid microneedles, the effect of 3D printing parameters on the final quality of printed microneedles was studied. In addition, the microneedles dimensions were varied to obtain microneedles with minimal dimensions and then, to highlight the limitations of the printer used. Solid microneedle with a needle tip diameter of 348 ± 13 μm; a needle base diameter of 744 ± 25 μm and a height of 1488 ± 18 μm as minimal dimensions were successfully printed. The FDM technique, when combined with chemical post‐fabrication etching, effectively improved the size and shape of the printed solid microneedles. However, despite efforts to print hollow microneedles, the FDM process proved insufficient for achieving the desired hollow structures, indicating the need for alternative methods or techniques. Hydrolysis treatment has reduced the dimensions of the printed PLA‐based microneedles. On the other hand, printing tests were carried out to make hollow microneedle patches. The drug reservoir is a part of the microneedle patch, located within the base of the patch. The orientation of the printed object and the addition of supports to the drug reservoir were studied to facilitate the printing of hollow parts.

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评估使用聚乳酸（PLA）制造实心和空心微针的熔融沉积模型（FDM）参数

本文研究了熔融沉积建模（FDM）工艺在制造实心和空心微针贴片方面的局限性。打印材料为聚乳酸（PLA），一种可生物降解且具有生物相容性的聚合物。对于实心微针，研究了三维打印参数对打印微针最终质量的影响。此外，还改变了微针的尺寸，以获得最小尺寸的微针，从而突出所用打印机的局限性。固体微针的针尖直径为 348 ± 13 μm，针底直径为 744 ± 25 μm，高度为 1488 ± 18 μm，这些都是成功打印出的最小尺寸。FDM 技术与制造后化学蚀刻相结合，有效改善了打印出的实心微针的尺寸和形状。然而，尽管努力打印空心微针，但事实证明 FDM 工艺不足以实现所需的空心结构，这表明需要采用其他方法或技术。水解处理减小了基于聚乳酸的打印微针的尺寸。另一方面，还进行了制作空心微针贴片的打印试验。药物储存器是微针贴片的一部分，位于贴片的底部。为了便于打印空心部件，研究了打印对象的方向以及在储药箱中添加支撑物的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymers for Advanced Technologies 工程技术-高分子科学

CiteScore

6.20

自引率

5.90%

发文量

337

审稿时长

2.1 months

期刊介绍： Polymers for Advanced Technologies is published in response to recent significant changes in the patterns of materials research and development. Worldwide attention has been focused on the critical importance of materials in the creation of new devices and systems. It is now recognized that materials are often the limiting factor in bringing a new technical concept to fruition and that polymers are often the materials of choice in these demanding applications. A significant portion of the polymer research ongoing in the world is directly or indirectly related to the solution of complex, interdisciplinary problems whose successful resolution is necessary for achievement of broad system objectives. Polymers for Advanced Technologies is focused to the interest of scientists and engineers from academia and industry who are participating in these new areas of polymer research and development. It is the intent of this journal to impact the polymer related advanced technologies to meet the challenge of the twenty-first century. Polymers for Advanced Technologies aims at encouraging innovation, invention, imagination and creativity by providing a broad interdisciplinary platform for the presentation of new research and development concepts, theories and results which reflect the changing image and pace of modern polymer science and technology. Polymers for Advanced Technologies aims at becoming the central organ of the new multi-disciplinary polymer oriented materials science of the highest scientific standards. It will publish original research papers on finished studies; communications limited to five typewritten pages plus three illustrations, containing experimental details; review articles of up to 40 pages; letters to the editor and book reviews. Review articles will normally be published by invitation. The Editor-in-Chief welcomes suggestions for reviews.