Antimicrobial polymer coatings on surfaces: preparation and activity

IF 2.8 4区 工程技术 Q2 POLYMER SCIENCE
Sangwon Ko, Jae-Young Lee, Duckshin Park, Kyunghoon Kim
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引用次数: 0

Abstract

Antimicrobial polymers have been intensively studied as a promising strategy to suppress the growth of microbes and mitigate the transmission of pathogens owing to their distinctive properties, such as high molecular weights, tunable structures, functionality, and polyvalency. Unlike the monomers, the repetitive structure and polyvalency of polymers enable robust interactions with the target surfaces to provide synergetic functionality. Antimicrobial polymers have a great variety of adjustable chain lengths and surface chemistry. Furthermore, their backbones can be functionalized with bioactive substituents to interact with cell membranes, lipids, and proteins. The surface coating methods and the resulting antimicrobial activities depend on polymer characteristics, such as the combination of monomers, synthetic methods, contact time, and substrates. This review focuses on representative antimicrobial polymers, including hydrophilic and ionic polymers, polysaccharides, and copolymers containing amine groups and quaternary ammonium cations (QACs). The surface application strategies and antimicrobial properties for each polymer type are also discussed to provide inspiration for the advanced design of antimicrobial polymers.

Graphical abstract

Schematic illustration of antifouling- or microbicidal polymers coated on solid surfaces.

Abstract Image

表面抗菌聚合物涂层:制备与活性
抗菌聚合物具有高分子量、可调结构、功能性和多价性等独特性质,是抑制微生物生长和减少病原体传播的一种有前途的策略。与单体不同,聚合物的重复结构和多价性使其能够与目标表面产生强有力的相互作用,从而提供协同功能。抗菌聚合物具有多种可调节的链长和表面化学性质。此外,它们的骨架可以用生物活性取代基进行功能化,从而与细胞膜、脂质和蛋白质相互作用。表面涂层方法和由此产生的抗菌活性取决于聚合物的特性,如单体的组合、合成方法、接触时间和基质。本综述重点介绍具有代表性的抗菌聚合物,包括亲水性聚合物、离子聚合物、多糖以及含胺基和季铵阳离子(QAC)的共聚物。还讨论了每种聚合物的表面应用策略和抗菌特性,以便为抗菌聚合物的高级设计提供灵感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Macromolecular Research
Macromolecular Research 工程技术-高分子科学
CiteScore
4.70
自引率
8.30%
发文量
100
审稿时长
1.3 months
期刊介绍: Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.
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