Pyrylium Compounds as Dual-transition pH Indicators and their Applications to Smartphone-assisted pH Determination

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-05 DOI:10.2174/0115734110333632240820073214

Doğukan Şakacı, Efdal Teknikel

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引用次数: 0

Abstract

Introduction: pH indicators have long been utilized for rapid pH determination, relying on color changes to indicate pH values. However, visual color detection suffers from low sensitivity due to the limitations of the human eye. In this study, we explored the use of pyrylium compounds as pH indicators. Method: Three pyrylium compounds were synthesized, and their pH-dependent UV-Vis absorption and color changes were investigated. UV-Vis absorption studies revealed distinct pH-dependent changes, enabling the compounds to function as dual-transition pH indicators. The pKa values of these indicators can be tuned by changing the substituent on the chromophore core. Results: Principal component analysis of the mixture of these three compounds demonstrated the ability of the system to measure pH with high precision, making it suitable for real sample analysis. Smartphone-assisted analysis was employed to exploit the potential of these indicators for widerange (4.0-13.5) pH determination. Conclusion: The obtained results demonstrated for the first time that pyrylium compounds can be used as dual-transition pH indicators. By modifying the substituents on this chromophore, indicators operating in different pH ranges can be obtained and utilized in smartphone-assisted pH detection.

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作为双跃迁 pH 指示剂的芘化合物及其在智能手机辅助 pH 值测定中的应用

导言：长期以来，pH 指示剂一直被用于快速测定 pH 值，依靠颜色变化来指示 pH 值。然而，由于人眼的局限性，视觉颜色检测的灵敏度较低。在本研究中，我们探索了使用吡铱化合物作为 pH 指示剂。方法：合成了三种芘化合物，并研究了它们随 pH 值变化的紫外可见吸收和颜色变化。紫外可见吸收研究显示了明显的 pH 依赖性变化，使这些化合物能够作为双过渡 pH 指示剂发挥作用。这些指示剂的 pKa 值可通过改变发色团核心上的取代基来调整。研究结果对这三种化合物混合物的主成分分析表明，该系统能够高精度地测量 pH 值，因此适用于实际样品分析。利用智能手机辅助分析，这些指示剂可用于更宽范围（4.0-13.5）的 pH 值测定。结论研究结果首次证明，吡铱化合物可用作双过渡 pH 指示剂。通过改变这种发色团上的取代基，可以获得在不同 pH 范围内工作的指示剂，并将其用于智能手机辅助 pH 检测。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.