Methanolic Extract of Morchella esculenta (Ascomycota), Prevents Chemotherapy Related Cardiotoxicity in Tumour Bearing Mice

IF 1.4 4区 生物学 Q4 MYCOLOGY
Sneha Das, Kainoor Janardhanan, Anit Mathew
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Abstract

Quest for bioactive that confer protection against chemotherapy induced cardio toxicity is a front-line area of cardio oncology research. Morel mushrooms have been used in traditional medicine to treat asthma, wound healing, cough, cold, indigestion, excessive phlegm and breathlessness. Morchella esculenta, commonly known as Guchhi in India is a highly prized culinary morel mushroom. Recent studies carried out in our laboratory have demonstrated significant cardioprotective effect of M. esculenta against doxorubicin induced cardiotoxicity. Since bioactive extracts of morel mushrooms were found to possess profound antioxidant activity, the possible interference of these extracts with antineoplastic activity of chemotherapy drugs is often surmised. Hence current study was undertaken to evaluate the effect of two anticancer drugs, doxorubicin and cyclophosphamide on solid tumour bearing mice treated with bioactive extract of M.esculenta. Solid tumour was induced by subcutaneous injection of Dalton’s Lymphoma Ascites (DLA) cells on the right hind limbs of Swiss albino mice. Animals were administered with various concentrations of methanol extract of M. esculenta following tumour induction. Tumour growth (volume and mass) was measured for four weeks after tumour induction. Cardioprotective effect of methanolic extract was assessed by determining cardiac injury markers levels in serum, antioxidant status in myocardium and histopathology of heart tissue. The results showed significant cardioprotective effect of methanol extract of M. esculenta on tumour bearing mice The findings also suggest that methanol extract of M. esculenta did not delimit the therapeutic effect of doxorubicin and cyclophosphamide despite its profound antioxidant activity.
莫氏菌(Ascomycota)甲醇提取物可预防肿瘤小鼠与化疗相关的心脏毒性
寻找能防止化疗引起的心脏毒性的生物活性物质是心脏肿瘤学研究的前沿领域。羊肚菌在传统医学中被用于治疗哮喘、伤口愈合、咳嗽、感冒、消化不良、痰多和呼吸困难。Morchella esculenta 在印度俗称 Guchhi,是一种非常珍贵的烹饪羊肚菌。我们实验室最近进行的研究表明,羊肚菌对多柔比星引起的心脏毒性有显著的保护作用。由于发现羊肚菌的生物活性提取物具有很强的抗氧化活性,人们经常推测这些提取物可能会干扰化疗药物的抗肿瘤活性。因此,本研究评估了两种抗癌药物多柔比星和环磷酰胺对用羊肚菌生物活性提取物治疗实体瘤小鼠的影响。在瑞士白化小鼠右后肢皮下注射道尔顿淋巴瘤腹水(DLA)细胞诱发实体瘤。诱导肿瘤后,给动物注射不同浓度的 M. esculenta 甲醇提取物。在诱导肿瘤后的四周内测量肿瘤的生长情况(体积和质量)。通过测定血清中心脏损伤标志物的水平、心肌的抗氧化状态和心脏组织的组织病理学,评估甲醇提取物对心脏的保护作用。研究结果表明,茜草甲醇提取物对罹患肿瘤的小鼠具有明显的心脏保护作用。研究结果还表明,尽管茜草甲醇提取物具有很强的抗氧化活性,但它并没有限制多柔比星和环磷酰胺的治疗效果。
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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