The preparation of trimethylolpropane ethoxylate-170-based antibacterial wound dressing materials containing allantoin via electrospinning method

Abstract

In this study, multifunctional wound and burn dressing material was developed to cover open wounds and protect them from external effects. Trimethylolpropane ethoxylate-170 (TMPE)-based polyurethane/polycaprolactone (PU/PCL) dressing materials were prepared with high biocompatibility and ordered nanofiber formation. Prepared PU/PCL dressing materials also contain allantoin additive to accelerate wound healing. Polyurethane structures were synthesized using solution polymerization technique from hexamethylene diisocyanate, polyethylene glycol-200, TMPE and Tween-40 monomers in different mole ratios. The obtained polyurethanes and dressing materials were characterized structurally, thermally and morphologically. Then, PCL, allantoin and gentamicin sulfate were added to these PU structures and converted into wound dressing materials by electrospinning technique. The allantoin release, mechanical analysis, antibacterial properties and biodegradability of the produced dressing materials were investigated. The obtained PU/PCL dressing materials were seen as flexible, durable and structural stable. These dressing materials have fiber diameter of approximately 500 nm. The tensile strength and Young's modulus of PU/PCL dressing materials are 2.22 ± 0.39 MPa and 1.04 ± 0.11 MPa. They released allantoin regularly for about 70 h and showed antibacterial properties. In addition, the prepared dressing materials have grade 1 biocompatibility. As a result, these dressing materials provide a good alternative to existing wound dressing materials.