Sequencing technology in sarcopenia: current research progress and future trends

IF 3.9 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yuxia Yang, Xiangji Meng, Xiaomei Dai, Jian Zhang, Jihang Dai, Jingcheng Wang, Wenyong Fei
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引用次数: 0

Abstract

BackgroundMuscle is an important tissue of the human body. Muscle atrophy is common in people of all ages, which will lead to human weakness and decline of motor function, which is one of the important causes of disability. The common methods of genomics research are transcriptome, proteomics and metabolomics, which are important means to explore the molecular pathology of diseases. In recent years, combinatorial research has been carried out on a large scale in the field of muscle atrophy. However, no author in this field has carried out bibliometrics and visual analysis.MethodsIn this study, articles related to the histological study of muscular dystrophy since 2000 were searched from the Web of Science core database (WoSCC). We will retrieve the results through CiteSpace, VosViewer and R for data statistics and visual analysis.ResultsIn this study, a total of 141 publications were collected, and the number of publications increased year by year. These 141 articles came from 1031 co-authors from 361 institutions in 31 countries and were published in 92 journals. A total of 6286 articles from 1383 journals were cited. Authors from American institutions have published the most articles and have been cited the most, and authors from other countries have also made considerable contributions.ConclusionThis is the first bibliometric and visual analysis of published research in the field of muscular dystrophy through systematic data retrieval and combined with a variety of bibliometric analysis tools. Through these data, we summarize the previous studies of scholars, and provide prospects for future research in the field.
肌少症的测序技术:当前研究进展与未来趋势
背景肌肉是人体的重要组织。肌肉萎缩常见于各个年龄段的人群,会导致人体乏力、运动功能下降,是致残的重要原因之一。基因组学研究的常用方法有转录组学、蛋白质组学和代谢组学,它们是探索疾病分子病理的重要手段。近年来,在肌肉萎缩领域开展了大规模的组合研究。本研究从科学网核心数据库(WoSCC)中检索了 2000 年以来与肌肉萎缩症组织学研究相关的文章。我们将通过 CiteSpace、VosViewer 和 R 对检索结果进行数据统计和可视化分析。结果本研究共收集到 141 篇论文,且论文数量逐年增加。这 141 篇文章来自 31 个国家 361 个机构的 1031 位共同作者,发表在 92 种期刊上。共有 1383 种期刊的 6286 篇文章被引用。来自美国机构的作者发表的文章最多,被引用的次数也最多,来自其他国家的作者也做出了相当大的贡献。通过这些数据,我们总结了学者们以往的研究,并对该领域未来的研究进行了展望。
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来源期刊
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
7.20
自引率
4.00%
发文量
1361
审稿时长
14 weeks
期刊介绍: Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.
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