Network Analysis of Cognitive-Behavioral Symptom Connectivity in OCD Subtypes: Evaluating SSRI Treatment Response and Resistance

IF 2.8 3区 心理学 Q2 PSYCHOLOGY, CLINICAL
Mohammadreza Davoudi, Rasha Mohammad Abdelrahman, Abdulnaser Fakhrou, Abbas Pourshahbaz
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Abstract

Background

This study employed network analysis to predict treatment responses, focusing on obsessive beliefs and symptoms within the contamination/cleaning and danger/checking subtypes of obsessive–compulsive disorder (OCD).

Methods

The study analyzed pre-test and post-test data from a 12-week open-label phase involving 140 patients who underwent a 12-week regimen of Selective Serotonin Reuptake Inhibitors (SSRIs), followed by evaluations. Participants were categorized based on their response to therapy and OCD subtypes. Network analysis was used to assess the interconnections among obsessive beliefs, symptoms, and treatment responses before and after the intervention within the identified OCD subtypes. Additionally, the study explored the network structure among patients with treatment-responsive OCD and those with treatment-resistant OCD within each subtype.

Results

In both subtypes, the pre-test network structure of treatment-resistant OCD exhibited stronger interconnections compared to treatment-responsive OCD. Additionally, a significant difference in global strength (P < 0.05) was observed between treatment-resistant OCD and treatment responders. In the initial assessment, which included both responders and non-responders, global strength and symptom connectivity were higher in the Checking subtype compared to the Contamination/Cleaning subtype (P < 0.05). Notably, the central symptoms in contamination/cleaning treatment-resistant OCD were obsessive beliefs related to "Disgust,” "Sexual," and "Punishment." In contrast, in the check/danger treatment-resistant OCD, the most central symptoms were "Sinful,” "Accident," and "Unsafe" obsessive beliefs, along with "Throwaway" obsessive symptoms.

Conclusions

Obsessive symptoms and beliefs can serve as predictors of treatment responses across different OCD subtypes.

Abstract Image

强迫症亚型的认知行为症状连接性网络分析:评估 SSRI 治疗反应和抗药性
背景本研究采用网络分析预测治疗反应,重点关注强迫症(OCD)的污染/清洁亚型和危险/检查亚型中的强迫观念和症状。方法本研究分析了为期12周的开放标签阶段的测试前和测试后数据,共有140名患者接受了为期12周的选择性羟色胺再摄取抑制剂(SSRIs)治疗,随后进行了评估。研究人员根据患者的治疗反应和强迫症亚型对其进行了分类。研究采用网络分析的方法,评估在已确定的强迫症亚型中,强迫观念、症状和干预前后的治疗反应之间的相互联系。此外,研究还探讨了每种亚型中治疗反应型强迫症患者和治疗耐受型强迫症患者之间的网络结构。结果在这两种亚型中,与治疗反应型强迫症相比,治疗耐受型强迫症患者测试前的网络结构表现出更强的相互联系。此外,治疗耐受性强迫症患者与治疗反应性强迫症患者之间的全局强度也存在显著差异(P < 0.05)。在包括有反应者和无反应者的初步评估中,检查亚型与污染/清洁亚型相比,总体强度和症状连接性更高(P <0.05)。值得注意的是,污染/清洁治疗耐药强迫症的中心症状是与 "厌恶"、"性 "和 "惩罚 "有关的强迫观念。与此相反,在检查/危险治疗耐药强迫症中,最主要的症状是 "罪恶"、"事故 "和 "不安全 "强迫观念以及 "丢弃 "强迫症状。
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来源期刊
Cognitive Therapy and Research
Cognitive Therapy and Research PSYCHOLOGY, CLINICAL-
CiteScore
5.30
自引率
0.00%
发文量
52
期刊介绍: Cognitive Therapy and Research (COTR) focuses on the investigation of cognitive processes in human adaptation and adjustment and cognitive behavioral therapy (CBT). It is an interdisciplinary journal welcoming submissions from diverse areas of psychology, including cognitive, clinical, developmental, experimental, personality, social, learning, affective neuroscience, emotion research, therapy mechanism, and pharmacotherapy.
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